biostudies-literatureLi XJiangsu Funding Program for Excellent Postdoctoral TalentNational Science and Technology Innovation 2030-Major Projects of Brain Science and Brain-Like Researchfunding for Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing UniversityNational Natural Science Foundation of China308-320https://www.ebi.ac.uk/biostudies/studies/S-EPMC11774012biostudies-literatureUnknown33(2)<h4>Objective</h4>The objective of this study was to investigate underlying mechanisms of long-term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) and cognition.<h4>Methods</h4>A total of 18 individuals with obesity (BMI ≥ 30 kg/m²) underwent LSG. Clinical data, cognitive scores, and brain magnetic resonance imaging scans were evaluated before LSG and 12 months after LSG. We employed voxel-based morphometry analysis and seed-based resting-state functional connectivity (RSFC) analysis to assess LSG-induced structural and functional changes in mOFC. Partial correlation analysis and univariate and multivariate linear regression models were used to explore associations among biochemical indexes, neuroimaging, cObesity (Silver Spring, Md.)Medial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy.PMC117740122022ZD02118002022-LCYJ-MS-032022-LCYJ-PY-152022ZB69482302172Zhang WLi XZhu ZChen JZhang ZZhang XSun XZhang BBi YDuan YfalseMedial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy.<h4>Objective</h4>The objective of this study was to investigate underlying mechanisms of long-term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) and cognition.<h4>Methods</h4>A total of 18 individuals with obesity (BMI ≥ 30 kg/m²) underwent LSG. Clinical data, cognitive scores, and brain magnetic resonance imaging scans were evaluated before LSG and 12 months after LSG. We employed voxel-based morphometry analysis and seed-based resting-state functional connectivity (RSFC) analysis to assess LSG-induced structural and functional changes in mOFC. Partial correlation analysis and univariate and multivariate linear regression models were used to explore associations among biochemical indexes, neuroimaging, c2025-01-01T00:00:00Z2025 Feb2025-04-18T16:47:39.956Z2025-04-07T04:14:01.866ZS-EPMC117740123987340010.1002/oby.24207