{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao CS"],"funding":["NEI NIH HHS","National Eye Institute"],"pagination":["124-131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11774680"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(2)"],"pubmed_abstract":["Purpose
To extend cross-sectional data on cytokine ratios (CRs) in dry eye disease (DED) signs by investigating longitudinal change in pro- to anti-inflammatory CRs and associations with change in DED signs and symptoms.Methods
Secondary analysis of fifty-four subjects [mean age 57.3 (SD 13.2) years, 85.2% female; 68.5% white] with ≥ 4 uL pooled tear volumes at months 0, 6, and 12. Pro-inflammatory (IL-1b, IL-6, IL-8, IL-17A, IFN-g, and TNF-a) to anti-inflammatory (IL-6, IL-10) cytokine ratios (CR) were calculated. DED signs (corneal and conjunctival staining scores, tear break-up time, Schirmer test, Meibomian gland plugging, tear osmolarity, composite sign severity score) and symptoms [Ocular Surface Disease Index (OSDI)] were measured. Changes over time in DED signs, sym"],"journal":["Current eye research"],"pubmed_title":["Longitudinal Analysis of Tear Cytokine Ratios in Association with Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study."],"pmcid":["PMC11774680"],"funding_grant_id":["U10 EY022881","R21EY031338","R21 EY031338","U10EY022881","U10 EY022879","U10EY022879"],"pubmed_authors":["Zhao CS","Ying GS","Dry Eye Assessment and Management (DREAM) Study Group","Chen Y","Asbell PA","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal Analysis of Tear Cytokine Ratios in Association with Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study.","description":"Purpose
To extend cross-sectional data on cytokine ratios (CRs) in dry eye disease (DED) signs by investigating longitudinal change in pro- to anti-inflammatory CRs and associations with change in DED signs and symptoms.Methods
Secondary analysis of fifty-four subjects [mean age 57.3 (SD 13.2) years, 85.2% female; 68.5% white] with ≥ 4 uL pooled tear volumes at months 0, 6, and 12. Pro-inflammatory (IL-1b, IL-6, IL-8, IL-17A, IFN-g, and TNF-a) to anti-inflammatory (IL-6, IL-10) cytokine ratios (CR) were calculated. DED signs (corneal and conjunctival staining scores, tear break-up time, Schirmer test, Meibomian gland plugging, tear osmolarity, composite sign severity score) and symptoms [Ocular Surface Disease Index (OSDI)] were measured. Changes over time in DED signs, sym","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-10T09:07:18.117Z","creation":"2026-06-10T03:12:40.644Z"},"accession":"S-EPMC11774680","cross_references":{"pubmed":["39267294"],"doi":["10.1080/02713683.2024.2398113"]}}