{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Polymeris AA"],"pubmed_abstract":["<h4>Importance</h4>The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation-associated ischemic stroke is unclear.<h4>Objective</h4>To investigate whether early DOAC treatment is associated with a net clinical benefit (NCB).<h4>Design, setting, and participants</h4>This was a post hoc analysis of the Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized clinical trial conducted across 103 sites in 15 countries in Europe, the Middle East, and Asia between November 6, 2017, and September 12, 2022, with a 90-day follow-up. Participants included patients with atrial fibrillation-associated acute ischemic stroke, excluding those with therapeutic ant"],"journal":["JAMA network open"],"pagination":["e2456307"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11775740"],"repository":["biostudies-literature"],"pubmed_title":["Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial."],"pmcid":["PMC11775740"],"pubmed_authors":["Anwar I","Stoop W","Harbison J","Storton S","Nambiar V","McCabe JJ","Del Gaudio N","Noone I","Royl G","Medlin F","Demeestere J","Dixon L","Wright F","Hussayni Husseini SA","Schelosky L","De Magistris IL","Menezes B","Hemelsoet D","Inoue M","Amina S","Muller Seljeseth Y","Rodic B","Sirimarco G","Nallasivan A","Eichel R","Kallmunzer B","Bonvin C","Paiva Nunes A","Vehoff J","Anjum T","Matsubara S","Sipila J","Niederhauser J","Oberndorfer S","Koga M","Bhatia R","Katan M","Mbroh J","Trelle S","Bianco G","Staykov D","Psychogios M","Kelly P","Sreedharan SE","Gupta V","Iguchi Y","Pap T","Von Oertzen TJ","Olave Bersas I","Gralla J","Sato T","Adeyemi AK","Huded V","Beyeler S","Altmann M","Rutgers MP","Olbert E","Liesz A","Bradley D","Stetefeld HR","Kunieda T","Bornstein NM","Alteheld L","Rani K","Muller M","Grimshaw B","Charisse D","Dhasan A","Sibolt G","De Herdt V","Khurana D","Kellert L","Vynckier J","Kahles T","Kulyk C","Nedeltchev K","Wilkinson A","Berberich A","Peters N","Krogias C","Dawson J","Giudici D","Selim M","Ihle-Hansen H","Wagner J","Szabo K","Mako M","Ostanek S","Sandset EC","de Sousa DA","Lemmens R","Albert SJ","Danilo T","Muller A","Guzman-Gutierrez G","Werring D","Haley M","Hostens A","Arnold M","Thomalla G","Delvoye F","Peeters A","Bolognese M","Strbian D","Caporale C","Scutelnic A","Paliantonis A","Marcelis E","Tiainen M","Vedamurthy A","Richter D","Vanacker P","Hidalgo R","Strambo D","Schell M","Gdovinova Z","Riebau S","Yperzeele L","Collins R","Ntaios G","Saukkonen AM","Klimcikova K","Onur OA","Matzusono K","Macha K","Globas C","Takayuki F","Marian R","Sharma AV","Mahajan N","Pinho E Melo T","Borisova V","Pfeilschifter W","Vosko M","Vanhoorne A","Dymond H","Humm AM","Zhang L","Ray S","Ciobanu C","Slade P","Cassidy T","Parthasarathy R","Mulcahy R","Polymeris AA","Fandler-Hofler S","Kellermair L","Kneihsl M","Pichler A","Alonso A","Fung C","Muresan IP","Devroye A","Goeldlin MB","Fischer U","Gentile L","Greulich M","Bassetti C","Fujimoto S","Krishnan M","Sargento-Freitas J","Loos C","Salanti G","Yakushiji Y","Yoshimura S","Asaf H","Fischer A","Desfontaines P","Galego S","Ryan D","Raty S","Fenzl S","Magrico M","ELAN Investigators","Thomas H","Tatlisumak T","Polavarapu N","Ferrari C","Tanaka R","Iype T","Martinez-Majander N","Tanaka K","Paciaroni M","Adamou A","Zini A","Karagkiozi E","Whyte C","Bonati LH","Goncalves Martins C","Schlemm E","Joan MacLeod M","Politz S","Pohner Skahjem M","Renaud S","Wilson A","Melancia D","Rezny-Kasprzak B","Clarke B","De Marchis GM","Salerno A","Morten Ronning O","Nabavi DG","Branca M","Costa T","Michalski D","Lang M","Kumar V","Abousleiman Y","Pelz J","Clarke S","Greisenegger S","Smith GM","Sousa JA","Barber M","Saxhaug Kristoffersen E","Marto JP","Schrammel D","Orion D","Gbadamosh L","Yoshimoto T","McAlpine C","Spetalen T","Hisanao A","Silimon N","Sylaja PN","Nakajima M","Cereda CW","Pope G","Gattringer T","Ringleb P","Koundal H","Offermann J","Marnane M","Michel P","Mosconi MG","Gumbinger C","Pandian JD","Shim G","Nair P","Garcia-Pons M","Pamidimukkala V","Vanpanteghem I","Falcou A","Soltesova K","Abdul-Rahim A","Poli S","Abend S","Pencz Z","Fisch L","Weder BJ","Annamalai A","Leker RR","Kato R","Hakim A","Smith K","Caracciolo NG","Horvath T","Esson D","Healy L","Seiffge DJ"],"additional_accession":[]},"is_claimable":false,"name":"Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.","description":"<h4>Importance</h4>The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation-associated ischemic stroke is unclear.<h4>Objective</h4>To investigate whether early DOAC treatment is associated with a net clinical benefit (NCB).<h4>Design, setting, and participants</h4>This was a post hoc analysis of the Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized clinical trial conducted across 103 sites in 15 countries in Europe, the Middle East, and Asia between November 6, 2017, and September 12, 2022, with a 90-day follow-up. Participants included patients with atrial fibrillation-associated acute ischemic stroke, excluding those with therapeutic ant","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T10:09:43.259Z","creation":"2025-04-03T23:26:41.006Z"},"accession":"S-EPMC11775740","cross_references":{"pubmed":["39874037"],"doi":["10.1001/jamanetworkopen.2024.56307"]}}