{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cardon A"],"funding":["Agence Nationale de la Recherche","Agence Nationale de la Recherche (French National Research Agency)"],"pagination":["1161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11779892"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Autoimmune liver diseases (AILD) involve dysregulated CD4 T cell responses against liver self-antigens, but how these autoreactive T cells relate to liver tissue pathology remains unclear. Here we perform single-cell transcriptomic and T cell receptor analyses of circulating, self-antigen-specific CD4 T cells from patients with AILD and identify a subset of liver-autoreactive CD4 T cells with a distinct B-helper transcriptional profile characterized by PD-1, TIGIT and HLA-DR expression. These cells share clonal relationships with expanded intrahepatic T cells and exhibit transcriptional signatures overlapping with tissue-resident T cells in chronically inflamed environments. Using a mouse model, we demonstrate that, following antigen recognition in the liver, CD4 T cells acquire an exhaust"],"journal":["Nature communications"],"pubmed_title":["Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting."],"pmcid":["PMC11779892"],"funding_grant_id":["ANR-19-CE17-0024"],"pubmed_authors":["Brouard S","Chevalier C","Schultheiß C","Kwok WW","Tanne F","Gil L","Gavlovsky PJ","Conchon S","Fourgeux C","Gournay J","Imbert A","Binder M","Cardon A","Lohse AW","Braud M","Dong C","Paul-Gilloteaux P","Milpied P","Guinebretiere T","Elkrief L","Poschmann J","Vavasseur F","Renand A","Danger R","Mosnier JF","Lannes A","Bernier L","Judor JP","Bardou-Jacquet E","Brusselle L","Silvain C","Ado S","Schnee M","Domene A","Khaldi M"],"additional_accession":[]},"is_claimable":false,"name":"Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting.","description":"Autoimmune liver diseases (AILD) involve dysregulated CD4 T cell responses against liver self-antigens, but how these autoreactive T cells relate to liver tissue pathology remains unclear. Here we perform single-cell transcriptomic and T cell receptor analyses of circulating, self-antigen-specific CD4 T cells from patients with AILD and identify a subset of liver-autoreactive CD4 T cells with a distinct B-helper transcriptional profile characterized by PD-1, TIGIT and HLA-DR expression. These cells share clonal relationships with expanded intrahepatic T cells and exhibit transcriptional signatures overlapping with tissue-resident T cells in chronically inflamed environments. Using a mouse model, we demonstrate that, following antigen recognition in the liver, CD4 T cells acquire an exhaust","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T07:26:33.919Z","creation":"2025-04-07T04:21:28.921Z"},"accession":"S-EPMC11779892","cross_references":{"pubmed":["39880819"],"doi":["10.1038/s41467-025-56363-2"]}}