{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(2)"],"submitter":["Halavina K"],"pubmed_abstract":["<h4>Background</h4>Degenerative severe aortic stenosis (AS) is treated by valve replacement to improve outcome. Despite diagnostic advancements, many AS patients are still diagnosed late with advanced heart failure.<h4>Objectives</h4>The aim of the study was to assess multiorgan dysfunction in severe AS using blood biomarkers and their association with quantitative fluid levels and clinical outcomes after transcatheter aortic valve implantation (TAVI).<h4>Methods</h4>Consecutive AS patients undergoing TAVI received comprehensive preinterventional assessment with serum biomarker profiles reflecting organ dysfunction and quantitative fluid overload (FO) using bioelectrical impedance spectroscopy. FO by bioelectrical impedance spectroscopy was defined according to a previously established cut"],"journal":["JACC. Advances"],"pagination":["101544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11780109"],"repository":["biostudies-literature"],"pubmed_title":["Multiorgan Dysfunction and its Association With Congestion and Outcome in Aortic Stenosis Treated With TAVI."],"pmcid":["PMC11780109"],"pubmed_authors":["Nitsche C","Jantsch C","Mascherbauer J","Mascherbauer K","Koschutnik M","Heitzinger G","Dannenberg V","Hemetsberger R","Petric F","Hauptmann L","Autherith M","Demirel C","Kammerlander AA","Koschatko S","Hengstenberg C","Bartko PE","Halavina K","Dona C","Rockel A","Andreas M"],"additional_accession":[]},"is_claimable":false,"name":"Multiorgan Dysfunction and its Association With Congestion and Outcome in Aortic Stenosis Treated With TAVI.","description":"<h4>Background</h4>Degenerative severe aortic stenosis (AS) is treated by valve replacement to improve outcome. Despite diagnostic advancements, many AS patients are still diagnosed late with advanced heart failure.<h4>Objectives</h4>The aim of the study was to assess multiorgan dysfunction in severe AS using blood biomarkers and their association with quantitative fluid levels and clinical outcomes after transcatheter aortic valve implantation (TAVI).<h4>Methods</h4>Consecutive AS patients undergoing TAVI received comprehensive preinterventional assessment with serum biomarker profiles reflecting organ dysfunction and quantitative fluid overload (FO) using bioelectrical impedance spectroscopy. FO by bioelectrical impedance spectroscopy was defined according to a previously established cut","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-22T10:26:52.892Z","creation":"2025-04-05T23:34:22.505Z"},"accession":"S-EPMC11780109","cross_references":{"pubmed":["39886314"],"doi":["10.1016/j.jacadv.2024.101544"]}}