biostudies-literatureUnknown161(4)Mintoff D<h4>Importance</h4>Variation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.<h4>Objective</h4>To investigate whether serum immunoglobulin levels, as a surrogate marker of humoral immunity, can identify individuals with hidradenitis suppurativa who have a specific disease-associated NCSTN variant.<h4>Design, setting, and participants</h4>Maltese individuals with hidradenitis suppurativa genotyped for a disease-associated NCSTN in-frame deletion prevalent in the local patient cohort were invited to participate in this cross-sectional stJAMA dermatology411-415https://www.ebi.ac.uk/biostudies/studies/S-EPMC11780503biostudies-literatureSerum Immunoglobulin G Levels and Nicastrin Variation in Hidradenitis Suppurativa.PMC11780503Pace NPMintoff DfalseSerum Immunoglobulin G Levels and Nicastrin Variation in Hidradenitis Suppurativa.<h4>Importance</h4>Variation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.<h4>Objective</h4>To investigate whether serum immunoglobulin levels, as a surrogate marker of humoral immunity, can identify individuals with hidradenitis suppurativa who have a specific disease-associated NCSTN variant.<h4>Design, setting, and participants</h4>Maltese individuals with hidradenitis suppurativa genotyped for a disease-associated NCSTN in-frame deletion prevalent in the local patient cohort were invited to participate in this cross-sectional st2025-01-01T00:00:00Z2025 Apr2026-06-14T06:00:41.517Z2026-06-14T03:15:18.455ZS-EPMC117805033987895610.1001/jamadermatol.2024.5684