{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(1)"],"submitter":["Sakai Y"],"pubmed_abstract":["<h4>Purpose</h4>Pyrrolidinophenone derivatives (PPs) are amphetamine-like designer drugs containing a pyrrolidine ring, and their adverse effects resemble those of methamphetamine (METH). Microglial activation has been recently suggested as a key event in eliciting the adverse effects against dysfunction of the central nervous system. The aim of this study is to clarify the mechanisms of microglial activation induced by PPs.<h4>Methods</h4>We employed the human microglial cell line HMC3 to assess microglial activation induced by PPs and evaluated the capacities for proliferation and interleukin-6 (IL-6) production that are characteristic features of the activation events.<h4>Results</h4>The WST-1 assay indicated that viability of HMC3 cells was increased by treatment with sublethal concent"],"journal":["Forensic toxicology"],"pagination":["142-154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11782452"],"repository":["biostudies-literature"],"pubmed_title":["α-Pyrrolidinooctanophenone facilitates activation of human microglial cells via ROS/STAT3-dependent pathway."],"pmcid":["PMC11782452"],"pubmed_authors":["Hattori J","Suenami K","Sakai Y","Jimbo S","Takayama T","Nagai A","Matsumura T","Michiue T","Morikawa Y","Ikari A","Matsunaga T"],"additional_accession":[]},"is_claimable":false,"name":"α-Pyrrolidinooctanophenone facilitates activation of human microglial cells via ROS/STAT3-dependent pathway.","description":"<h4>Purpose</h4>Pyrrolidinophenone derivatives (PPs) are amphetamine-like designer drugs containing a pyrrolidine ring, and their adverse effects resemble those of methamphetamine (METH). Microglial activation has been recently suggested as a key event in eliciting the adverse effects against dysfunction of the central nervous system. The aim of this study is to clarify the mechanisms of microglial activation induced by PPs.<h4>Methods</h4>We employed the human microglial cell line HMC3 to assess microglial activation induced by PPs and evaluated the capacities for proliferation and interleukin-6 (IL-6) production that are characteristic features of the activation events.<h4>Results</h4>The WST-1 assay indicated that viability of HMC3 cells was increased by treatment with sublethal concent","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T14:05:36.535Z","creation":"2025-04-04T14:05:36.535Z"},"accession":"S-EPMC11782452","cross_references":{"pubmed":["39652148"],"doi":["10.1007/s11419-024-00708-x"]}}