{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(2)"],"submitter":["Hoshide S"],"pubmed_abstract":["<h4>Background</h4>There has been no study about the association of longitudinal change in ambulatory blood pressure (BP) variability and level with cognitive decline.<h4>Objectives</h4>The purpose of the study was to evaluate whether BP changes via ambulatory BP monitoring predict cognitive decline progression.<h4>Methods</h4>Twice-annual ambulatory BP readings were examined during 5 years and their relationship with changes in the Japanese version of the Montreal Cognitive Assessment (MoCA-J) scores. BP variability was assessed using SD, coefficient of variation, and average real variability (ARV). Cognitive decline, defined as a change in the MoCA-J score, was assessed, with the threshold set at the quartile showing the greatest decrease, which we categorized as cognitive dysfunction (-4 points or less).<h4>Results</h4>Among 206 participants (mean age 79.9 [± 7.5] years), baseline 24-hour systolic blood pressure (SBP)/diastolic blood pressure (DBP) averaged 115.2/67.0 mm Hg. Over 4.98 years (IQR: 4.94-5.04 years), MoCA-J scores showed a nonsignificant decline from 20.2 (± 0.4) to 19.9 (± 0.4). A generalized linear mixed model showed that increased SD of daytime SBP (-0.064 [95% CI: -0.121 to -0.007]; <i>P</i> < 0.029) and DBP (-0.125 [95% CI: -0.213 to -0.037]; <i>P</i> = 0.005) were significantly linked to MoCA-J score decline, with similar trends for most measures except nighttime ARV. Logistic regression revealed higher ORs for cognitive decline with increased SD of daytime SBP (1.52 [95% CI: 1.18-1.96]; <i>P</i> = 0.001) and DBP (1.36 [95% CI: 1.09-1.71]; <i>P</i> = 0.007), consistent across coefficient of variation and ARV. No association was found between changes in BP level and MoCA-J score decline.<h4>Conclusions</h4>In older adults with controlled BP, increased BP variability was linked to cognitive decline, warranting further study as a prevention target."],"journal":["JACC. Advances"],"pagination":["101560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11782814"],"repository":["biostudies-literature"],"pubmed_title":["Association of Longitudinal Change in Ambulatory Blood Pressure With Cognitive Decline in Older Adults."],"pmcid":["PMC11782814"],"pubmed_authors":["Nishizawa M","Kanegae H","Kario K","Hoshide S"],"additional_accession":[]},"is_claimable":false,"name":"Association of Longitudinal Change in Ambulatory Blood Pressure With Cognitive Decline in Older Adults.","description":"<h4>Background</h4>There has been no study about the association of longitudinal change in ambulatory blood pressure (BP) variability and level with cognitive decline.<h4>Objectives</h4>The purpose of the study was to evaluate whether BP changes via ambulatory BP monitoring predict cognitive decline progression.<h4>Methods</h4>Twice-annual ambulatory BP readings were examined during 5 years and their relationship with changes in the Japanese version of the Montreal Cognitive Assessment (MoCA-J) scores. BP variability was assessed using SD, coefficient of variation, and average real variability (ARV). Cognitive decline, defined as a change in the MoCA-J score, was assessed, with the threshold set at the quartile showing the greatest decrease, which we categorized as cognitive dysfunction (-4 points or less).<h4>Results</h4>Among 206 participants (mean age 79.9 [± 7.5] years), baseline 24-hour systolic blood pressure (SBP)/diastolic blood pressure (DBP) averaged 115.2/67.0 mm Hg. Over 4.98 years (IQR: 4.94-5.04 years), MoCA-J scores showed a nonsignificant decline from 20.2 (± 0.4) to 19.9 (± 0.4). A generalized linear mixed model showed that increased SD of daytime SBP (-0.064 [95% CI: -0.121 to -0.007]; <i>P</i> < 0.029) and DBP (-0.125 [95% CI: -0.213 to -0.037]; <i>P</i> = 0.005) were significantly linked to MoCA-J score decline, with similar trends for most measures except nighttime ARV. Logistic regression revealed higher ORs for cognitive decline with increased SD of daytime SBP (1.52 [95% CI: 1.18-1.96]; <i>P</i> = 0.001) and DBP (1.36 [95% CI: 1.09-1.71]; <i>P</i> = 0.007), consistent across coefficient of variation and ARV. No association was found between changes in BP level and MoCA-J score decline.<h4>Conclusions</h4>In older adults with controlled BP, increased BP variability was linked to cognitive decline, warranting further study as a prevention target.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-05T09:32:57.326Z","creation":"2025-04-05T09:32:57.326Z"},"accession":"S-EPMC11782814","cross_references":{"pubmed":["39898343"],"doi":["10.1016/j.jacadv.2024.101560"]}}