{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee EH"],"funding":["Korea University Guro Hospital","European Union Joint Program for Neurodegenerative Disorders","Swedish government and the County Councils","Korea National Institute of Health","Swedish Research Council","Hjärnfonden, Sweden","National Research Foundation of Korea","Swedish Alzheimer Foundation","La Fondation Recherche Alzheimer","Familjen Rönströms Stiftelse","Kirsten og Freddy Johansens Fond","Ministry of Health & Welfare and Ministry of Science and ICT","Alzheimer's Association 2021 Zenith Award","Ministry of Science and ICT, South Korea","Alzheimer's Association","Samsung Medical Center"],"pagination":["e14368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11782842"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Introduction</h4>We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET).<h4>Methods</h4>A total of 2935 participants underwent blood sampling for measurements of plasma Aβ42/40 ratio, phosphorylated tau 217 (p-tau217; ALZpath), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) levels using single-molecule array and Aβ PET. Laboratory findings were collected using a routine blood test battery.<h4>Results</h4>Aβ-independent factors included hemoglobin and estimated glomerular filtration rate (eGFR) for p-tau217 and hemoglobin, eGFR, and triiodothyronine (T<sub>3</sub>) for GFAP and NfL. Aβ-dependent factors included apolipoprotein E genotypes, body mass index status for Aβ42/40, p-tau217, GFAP, and NfL. However, these factors exhibited negligible or modest effects on Aβ positivity on PET.<h4>Discussion</h4>Our findings highlight the importance of accurately interpreting plasma biomarkers for predicting Aβ uptake in real-world settings.<h4>Highlights</h4>We investigated factor-Alzheimer's disease plasma biomarker associations in a large Korean cohort. Hemoglobin and estimated glomerular filtration rate affect the biomarkers independently of brain amyloid beta (Aβ). Apolipoprotein E genotypes and body mass index status affect the biomarkers dependent on brain Aβ. Addition of Aβ-independent factors shows negligible effect in predicting Aβ positivity. Adjusting for Aβ-dependent factors shows a modest effect in predicting Aβ positivity."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors."],"pmcid":["PMC11782842"],"funding_grant_id":["#AF-930351","SG-23-1038904 QC","#2022-00732","#ALZ2022-0006","#ALFGBG-715986","NRF-2019R1A5A2027340","ZEN-21-848495","RS-2020-KH106434","Artificial Intelligence Innovation Hub","2024-ER1003-00","#ALFGBG-965240","#2017-00915","#FO2017-0243","#AF-994551","No.O2400251","RS-2022-KH127756","No.RS-2021-II212068","JPND2019-466-236","#AF-968270","#AF-939721","#SMX1240561"],"pubmed_authors":["Yun J","Kim JP","Na DL","Seo SW","Kim HJ","K‐ROAD study group","Jang H","Zetterberg H","Ashton NJ","Kang SH","Shin D","Cheon BK","Kim YJ","Ham H","Lee EH","Gonzalez-Ortiz F","Yoo H","Blennow K"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors.","description":"<h4>Introduction</h4>We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET).<h4>Methods</h4>A total of 2935 participants underwent blood sampling for measurements of plasma Aβ42/40 ratio, phosphorylated tau 217 (p-tau217; ALZpath), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) levels using single-molecule array and Aβ PET. Laboratory findings were collected using a routine blood test battery.<h4>Results</h4>Aβ-independent factors included hemoglobin and estimated glomerular filtration rate (eGFR) for p-tau217 and hemoglobin, eGFR, and triiodothyronine (T<sub>3</sub>) for GFAP and NfL. Aβ-dependent factors included apolipoprotein E genotypes, body mass index status for Aβ42/40, p-tau217, GFAP, and NfL. However, these factors exhibited negligible or modest effects on Aβ positivity on PET.<h4>Discussion</h4>Our findings highlight the importance of accurately interpreting plasma biomarkers for predicting Aβ uptake in real-world settings.<h4>Highlights</h4>We investigated factor-Alzheimer's disease plasma biomarker associations in a large Korean cohort. Hemoglobin and estimated glomerular filtration rate affect the biomarkers independently of brain amyloid beta (Aβ). Apolipoprotein E genotypes and body mass index status affect the biomarkers dependent on brain Aβ. Addition of Aβ-independent factors shows negligible effect in predicting Aβ positivity. Adjusting for Aβ-dependent factors shows a modest effect in predicting Aβ positivity.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T20:57:10.949Z","creation":"2025-04-04T20:57:10.949Z"},"accession":"S-EPMC11782842","cross_references":{"pubmed":["39535473"],"doi":["10.1002/alz.14368"]}}