{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["56"],"submitter":["Nilsen DWT"],"pubmed_abstract":["<h4>Background</h4>α1-antichymotrypsin (SERPINA3), high sensitivity C-reactive protein (hsCRP) and pentraxin 3 (PTX3) are acute phase proteins triggered by inflammation, whereas D-dimer, fibrin monomer and α2-antiplasmin are thrombo-fibrinolytic markers. Sex differences in relation to cardiovascular disease were investigated.<h4>Methods</h4>A total of 871 consecutive patients (61.0 % males; females: 77.3 years, males 69.1 years) were included. Of these, 380 were diagnosed with an acute myocardial infarction (MI). Stepwise Cox regression models, applying normalized continuous log<sub>e</sub>/SD values, were fitted for the biomarkers with all-cause mortality, MI and stroke, respectively, and a composite endpoint within 7 years as the dependent variables.<h4>Results</h4>Except for α2-antiplas"],"journal":["International journal of cardiology. Heart & vasculature"],"pagination":["101600"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11782882"],"repository":["biostudies-literature"],"pubmed_title":["Sex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin."],"pmcid":["PMC11782882"],"pubmed_authors":["Poenitz V","Ueland T","Grundt H","Brugger-Andersen T","Staines H","Michelsen AE","Nilsen DWT","Aukrust P","Aarsetoey R"],"additional_accession":[]},"is_claimable":false,"name":"Sex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin.","description":"<h4>Background</h4>α1-antichymotrypsin (SERPINA3), high sensitivity C-reactive protein (hsCRP) and pentraxin 3 (PTX3) are acute phase proteins triggered by inflammation, whereas D-dimer, fibrin monomer and α2-antiplasmin are thrombo-fibrinolytic markers. Sex differences in relation to cardiovascular disease were investigated.<h4>Methods</h4>A total of 871 consecutive patients (61.0 % males; females: 77.3 years, males 69.1 years) were included. Of these, 380 were diagnosed with an acute myocardial infarction (MI). Stepwise Cox regression models, applying normalized continuous log<sub>e</sub>/SD values, were fitted for the biomarkers with all-cause mortality, MI and stroke, respectively, and a composite endpoint within 7 years as the dependent variables.<h4>Results</h4>Except for α2-antiplas","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T23:18:14.226Z","creation":"2025-04-04T20:56:37.505Z"},"accession":"S-EPMC11782882","cross_references":{"pubmed":["39897419"],"doi":["10.1016/j.ijcha.2025.101600"]}}