biostudies-literatureUnknown56Nilsen DWT<h4>Background</h4>α1-antichymotrypsin (SERPINA3), high sensitivity C-reactive protein (hsCRP) and pentraxin 3 (PTX3) are acute phase proteins triggered by inflammation, whereas D-dimer, fibrin monomer and α2-antiplasmin are thrombo-fibrinolytic markers. Sex differences in relation to cardiovascular disease were investigated.<h4>Methods</h4>A total of 871 consecutive patients (61.0 % males; females: 77.3 years, males 69.1 years) were included. Of these, 380 were diagnosed with an acute myocardial infarction (MI). Stepwise Cox regression models, applying normalized continuous log_e/SD values, were fitted for the biomarkers with all-cause mortality, MI and stroke, respectively, and a composite endpoint within 7 years as the dependent variables.<h4>Results</h4>Except for α2-antiplasInternational journal of cardiology. Heart & vasculature101600https://www.ebi.ac.uk/biostudies/studies/S-EPMC11782882biostudies-literatureSex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin.PMC11782882Poenitz VUeland TGrundt HBrugger-Andersen TStaines HMichelsen AENilsen DWTAukrust PAarsetoey RfalseSex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin.<h4>Background</h4>α1-antichymotrypsin (SERPINA3), high sensitivity C-reactive protein (hsCRP) and pentraxin 3 (PTX3) are acute phase proteins triggered by inflammation, whereas D-dimer, fibrin monomer and α2-antiplasmin are thrombo-fibrinolytic markers. Sex differences in relation to cardiovascular disease were investigated.<h4>Methods</h4>A total of 871 consecutive patients (61.0 % males; females: 77.3 years, males 69.1 years) were included. Of these, 380 were diagnosed with an acute myocardial infarction (MI). Stepwise Cox regression models, applying normalized continuous log_e/SD values, were fitted for the biomarkers with all-cause mortality, MI and stroke, respectively, and a composite endpoint within 7 years as the dependent variables.<h4>Results</h4>Except for α2-antiplas2025-01-01T00:00:00Z2025 Feb2026-06-01T23:18:14.226Z2025-04-04T20:56:37.505ZS-EPMC117828823989741910.1016/j.ijcha.2025.101600