{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zumwinkel M"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","European Research Council"],"pagination":["e0029724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11784352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["93(1)"],"pubmed_abstract":["Protection against infections with intracellular bacteria requires the interaction of macrophages and T-lymphocytes, including CD8<sup>+</sup> T cells. Recently, the expression of natural killer cell receptors NKG2A and NKG2C was introduced as markers of CD8<sup>+</sup> T-cell subsets. The goal of this study was to functionally characterize human NKG2A and NKG2C-expressing T cells using the major pathogen <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) as a model organism. Sorted NKG2 populations were analyzed for their capacity to proliferate and degranulate and their intracellular expression of cytotoxic molecules. Cytokine release and the effect on bacterial growth were assessed after coculture of NKG2 populations with <i>Mtb</i>-infected macrophages. NKG2A<sup>+</sup> T cells released h"],"journal":["Infection and immunity"],"pubmed_title":["Polycytotoxic T cells mediate antimicrobial activity against intracellular &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt;."],"pmcid":["PMC11784352"],"funding_grant_id":["101080309","101080309-2","316249678","425963938"],"pubmed_authors":["Grieshober M","Stenger S","Romahn V","Chirambo A","Zumwinkel M","Burger M","Mwandumba H","Zahnle M"],"additional_accession":[]},"is_claimable":false,"name":"Polycytotoxic T cells mediate antimicrobial activity against intracellular &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt;.","description":"Protection against infections with intracellular bacteria requires the interaction of macrophages and T-lymphocytes, including CD8<sup>+</sup> T cells. Recently, the expression of natural killer cell receptors NKG2A and NKG2C was introduced as markers of CD8<sup>+</sup> T-cell subsets. The goal of this study was to functionally characterize human NKG2A and NKG2C-expressing T cells using the major pathogen <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) as a model organism. Sorted NKG2 populations were analyzed for their capacity to proliferate and degranulate and their intracellular expression of cytotoxic molecules. Cytokine release and the effect on bacterial growth were assessed after coculture of NKG2 populations with <i>Mtb</i>-infected macrophages. NKG2A<sup>+</sup> T cells released h","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T22:22:40.025Z","creation":"2025-04-04T22:22:40.025Z"},"accession":"S-EPMC11784352","cross_references":{"pubmed":["39660897"],"doi":["10.1128/iai.00297-24"]}}