biostudies-literatureUnknown8(1)Maiga AW<h4>Importance</h4>While national guidelines recommend avoidance of hypoxia, hypotension, and hypocarbia in the prehospital care of traumatic brain injury (TBI), limited data validate the association of these adverse physiologic events with TBI outcomes.<h4>Objective</h4>To validate the associations of prehospital hypoxia, hypotension, and hypocarbia with TBI outcomes in a US national trauma network.<h4>Design, setting, and participants</h4>This cohort study examined data from 8 level I trauma centers and their affiliated ground and air emergency medical services (EMS) agencies in the Linking Investigations in Trauma and Emergency Services (LITES) Network from January 1, 2017, to June 30, 2021. Adult patients (aged ≥18 years) with confirmed TBI (head Abbreviated Injury Score [AIS] of 1-6) JAMA network opene2457506https://www.ebi.ac.uk/biostudies/studies/S-EPMC11786231biostudies-literatureAdverse Prehospital Events and Outcomes After Traumatic Brain Injury.PMC11786231Ostermayer DGPatel MBCotton BAMoore EEGuyette FXHarbrecht BGLin HSWisniewski SRWilson CTJoseph BWang HEMaiga AWSperry JLBrown JBSchreiber MAfalseAdverse Prehospital Events and Outcomes After Traumatic Brain Injury.<h4>Importance</h4>While national guidelines recommend avoidance of hypoxia, hypotension, and hypocarbia in the prehospital care of traumatic brain injury (TBI), limited data validate the association of these adverse physiologic events with TBI outcomes.<h4>Objective</h4>To validate the associations of prehospital hypoxia, hypotension, and hypocarbia with TBI outcomes in a US national trauma network.<h4>Design, setting, and participants</h4>This cohort study examined data from 8 level I trauma centers and their affiliated ground and air emergency medical services (EMS) agencies in the Linking Investigations in Trauma and Emergency Services (LITES) Network from January 1, 2017, to June 30, 2021. Adult patients (aged ≥18 years) with confirmed TBI (head Abbreviated Injury Score [AIS] of 1-6) 2025-01-01T00:00:00Z2025 Jan2025-04-04T00:01:31.781Z2025-04-04T00:01:31.781ZS-EPMC117862313988861410.1001/jamanetworkopen.2024.57506