{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Talyzina IA"],"funding":["NINDS NIH HHS","NCI NIH HHS","NIAMS NIH HHS"],"pagination":["102550"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11788071"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84"],"pubmed_abstract":["Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert them into ionic currents that regulate senses of taste, smell, vision, hearing, touch and contribute to perception of temperature and pain. TRP channels are implicated in the pathogenesis of numerous human diseases, including cancers, and represent one of the most ardently pursued drug targets. Recent advances in structural biology, particularly associated with the cryo-EM \"resolution revolution\", yielded numerous TRP channel structures in complex with ligands that might have therapeutic potential. In this review, we describe the recent progress in TRP channel structural biology, focusing on the description of identified binding sites f"],"journal":["Current opinion in chemical biology"],"pubmed_title":["Forty sites of TRP channel regulation."],"pmcid":["PMC11788071"],"funding_grant_id":["R01 AR078814","R37 NS083660","R01 NS107253","R01 CA206573"],"pubmed_authors":["Talyzina IA","Sobolevsky AI","Nadezhdin KD"],"additional_accession":[]},"is_claimable":false,"name":"Forty sites of TRP channel regulation.","description":"Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert them into ionic currents that regulate senses of taste, smell, vision, hearing, touch and contribute to perception of temperature and pain. TRP channels are implicated in the pathogenesis of numerous human diseases, including cancers, and represent one of the most ardently pursued drug targets. Recent advances in structural biology, particularly associated with the cryo-EM \"resolution revolution\", yielded numerous TRP channel structures in complex with ligands that might have therapeutic potential. In this review, we describe the recent progress in TRP channel structural biology, focusing on the description of identified binding sites f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-02T21:07:56.836Z","creation":"2025-04-19T14:09:52.28Z"},"accession":"S-EPMC11788071","cross_references":{"pubmed":["39615427"],"doi":["10.1016/j.cbpa.2024.102550"]}}