{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahmad J"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["e16242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11790010"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(2)"],"pubmed_abstract":["<h4>Background and aims</h4>Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DILIN).<h4>Methods</h4>DILIN cases with MP as a suspected drug were reviewed. DILIN causality scoring was assigned on a 5-point scale (definite, highly likely, probable, possible, unlikely). All cases with MP causality scores of definite, highly likely or probable were analysed. HLA data from direct sequencing were analysed.<h4>Results</h4>Eleven cases of definite, highly likely, or probable MP DILI were identified. The median age was 48 years; 73% were female; median latency to onset was 30 days; 55% were jaundiced; and all had hepatocellular injury with one patient requiring transplantation. Nine of the 11 cases were in patients with multiple sclerosis (MS). Liver biopsies in 7 cases revealed mild acute hepatitis with/without cholestasis. HLA data demonstrated that HLA-DRB1*15:01, the primary HLA class II allele associated with MS was over-represented. HLA-DQB1*06:02-HLA-DQA1*01:02 which is haplotypic with the HLA-DRB1*15 haplotype was more common in the MP DILI cases compared to other DILI controls (p = 0.03) and to DILI controls exposed to MP (p = 0.04).<h4>Conclusion</h4>MP DILI is characterised by hepatocellular injury, short latency and generally rapid recovery. There was no independent HLA haplotype associated with MP DILI."],"journal":["Liver international : official journal of the International Association for the Study of the Liver"],"pubmed_title":["Liver Injury due to Intravenous Methylprednisolone in the Drug-Induced Liver Injury Network."],"pmcid":["PMC11790010"],"funding_grant_id":["U01 DK065201","U01 DK065211","U01 DK083020","U01 DK065184","U01 DK083027","U01 DK100928","U24 DK065176"],"pubmed_authors":["Drug‐Induced Liver Injury Network","Hayashi PH","Hoofnagle JH","Phillips E","Barnhart HX","Fontana RJ","Ahmad J","Chalasani N","Dellinger A","Li YJ","Kleiner DE"],"additional_accession":[]},"is_claimable":false,"name":"Liver Injury due to Intravenous Methylprednisolone in the Drug-Induced Liver Injury Network.","description":"<h4>Background and aims</h4>Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DILIN).<h4>Methods</h4>DILIN cases with MP as a suspected drug were reviewed. DILIN causality scoring was assigned on a 5-point scale (definite, highly likely, probable, possible, unlikely). All cases with MP causality scores of definite, highly likely or probable were analysed. HLA data from direct sequencing were analysed.<h4>Results</h4>Eleven cases of definite, highly likely, or probable MP DILI were identified. The median age was 48 years; 73% were female; median latency to onset was 30 days; 55% were jaundiced; and all had hepatocellular injury with one patient requiring transplantation. Nine of the 11 cases were in patients with multiple sclerosis (MS). Liver biopsies in 7 cases revealed mild acute hepatitis with/without cholestasis. HLA data demonstrated that HLA-DRB1*15:01, the primary HLA class II allele associated with MS was over-represented. HLA-DQB1*06:02-HLA-DQA1*01:02 which is haplotypic with the HLA-DRB1*15 haplotype was more common in the MP DILI cases compared to other DILI controls (p = 0.03) and to DILI controls exposed to MP (p = 0.04).<h4>Conclusion</h4>MP DILI is characterised by hepatocellular injury, short latency and generally rapid recovery. There was no independent HLA haplotype associated with MP DILI.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-16T07:24:34.288Z","creation":"2026-06-16T03:10:09.949Z"},"accession":"S-EPMC11790010","cross_references":{"pubmed":["39803998"],"doi":["10.1111/liv.16242"]}}