biostudies-literatureAhmad JNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney Diseasese16242https://www.ebi.ac.uk/biostudies/studies/S-EPMC11790010biostudies-literatureUnknown45(2)<h4>Background and aims</h4>Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DILIN).<h4>Methods</h4>DILIN cases with MP as a suspected drug were reviewed. DILIN causality scoring was assigned on a 5-point scale (definite, highly likely, probable, possible, unlikely). All cases with MP causality scores of definite, highly likely or probable were analysed. HLA data from direct sequencing were analysed.<h4>Results</h4>Eleven cases of definite, highly likely, or probable MP DILI were identified. The median age was 48 years; 73% were female; median latency to onset was 30 days; 55% were jaundiced; and all had hepatocellular injury with one patient requiring transplantation. Nine of the 11 cases were in patients with multiple sclerosis (MS). Liver biopsies in 7 cases revealed mild acute hepatitis with/without cholestasis. HLA data demonstrated that HLA-DRB1*15:01, the primary HLA class II allele associated with MS was over-represented. HLA-DQB1*06:02-HLA-DQA1*01:02 which is haplotypic with the HLA-DRB1*15 haplotype was more common in the MP DILI cases compared to other DILI controls (p = 0.03) and to DILI controls exposed to MP (p = 0.04).<h4>Conclusion</h4>MP DILI is characterised by hepatocellular injury, short latency and generally rapid recovery. There was no independent HLA haplotype associated with MP DILI.Liver international : official journal of the International Association for the Study of the LiverLiver Injury due to Intravenous Methylprednisolone in the Drug-Induced Liver Injury Network.PMC11790010U01 DK065201U01 DK065211U01 DK083020U01 DK065184U01 DK083027U01 DK100928U24 DK065176Drug‐Induced Liver Injury NetworkHayashi PHHoofnagle JHPhillips EBarnhart HXFontana RJAhmad JChalasani NDellinger ALi YJKleiner DEfalseLiver Injury due to Intravenous Methylprednisolone in the Drug-Induced Liver Injury Network.<h4>Background and aims</h4>Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DILIN).<h4>Methods</h4>DILIN cases with MP as a suspected drug were reviewed. DILIN causality scoring was assigned on a 5-point scale (definite, highly likely, probable, possible, unlikely). All cases with MP causality scores of definite, highly likely or probable were analysed. HLA data from direct sequencing were analysed.<h4>Results</h4>Eleven cases of definite, highly likely, or probable MP DILI were identified. The median age was 48 years; 73% were female; median latency to onset was 30 days; 55% were jaundiced; and all had hepatocellular injury with one patient requiring transplantation. Nine of the 11 cases were in patients with multiple sclerosis (MS). Liver biopsies in 7 cases revealed mild acute hepatitis with/without cholestasis. HLA data demonstrated that HLA-DRB1*15:01, the primary HLA class II allele associated with MS was over-represented. HLA-DQB1*06:02-HLA-DQA1*01:02 which is haplotypic with the HLA-DRB1*15 haplotype was more common in the MP DILI cases compared to other DILI controls (p = 0.03) and to DILI controls exposed to MP (p = 0.04).<h4>Conclusion</h4>MP DILI is characterised by hepatocellular injury, short latency and generally rapid recovery. There was no independent HLA haplotype associated with MP DILI.2025-01-01T00:00:00Z2025 Feb2026-06-16T07:24:34.288Z2026-06-16T03:10:09.949ZS-EPMC117900103980399810.1111/liv.16242