biostudies-literatureMyers LCNational Heart, Lung and Blood InstituteRegeneronCSL BehringNHLBI NIH HHSJansseniRhythm TechnologiesJanssen Research and DevelopmentNIGMS NIH HHS565-571https://www.ebi.ac.uk/biostudies/studies/S-EPMC11790280biostudies-literatureUnknown19(7)<h4>Background</h4>New-onset atrial fibrillation (AF) during sepsis is common, but models designed to stratify stroke risk excluded patients with secondary AF. We assessed the predictive validity of CHA₂DS₂VASc scores among patients with new-onset AF during sepsis and developed a novel stroke prediction model incorporating presepsis and intrasepsis characteristics.<h4>Methods</h4>We included patients ≥40 years old who survived hospitalizations with sepsis and new-onset AF across 21 Kaiser Permanente Northern California hospitals from January 1, 2011 to September 30, 2017. We calculated the area under the receiver operating curve (AUC) for CHA₂DS₂VASc scores to predict stroke or transient ischemic attack (TIA) within 1 year after a hospitalizationJournal of hospital medicinePredicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation.PMC11790280K23 GM129661R01 HL1397515R01HL139751 02Peltan IDDesai MClancy HLiu VXDevis YThai KKLu YWGo ASKipnis PNeugebauer RSBrown SMMyers LCWalkey AJfalsePredicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation.<h4>Background</h4>New-onset atrial fibrillation (AF) during sepsis is common, but models designed to stratify stroke risk excluded patients with secondary AF. We assessed the predictive validity of CHA₂DS₂VASc scores among patients with new-onset AF during sepsis and developed a novel stroke prediction model incorporating presepsis and intrasepsis characteristics.<h4>Methods</h4>We included patients ≥40 years old who survived hospitalizations with sepsis and new-onset AF across 21 Kaiser Permanente Northern California hospitals from January 1, 2011 to September 30, 2017. We calculated the area under the receiver operating curve (AUC) for CHA₂DS₂VASc scores to predict stroke or transient ischemic attack (TIA) within 1 year after a hospitalization2024-01-01T00:00:00Z2024 Jul2025-04-19T16:23:26.64Z2025-04-19T16:23:26.64ZS-EPMC117902803859491810.1002/jhm.13343