biostudies-literatureOberlin LENIA NIH HHSNIMH NIH HHSNational Institutes of Health167-176https://www.ebi.ac.uk/biostudies/studies/S-EPMC11790366biostudies-literatureUnknown59(3)<h4>Objectives</h4>To evaluate the association between cardiorespiratory fitness (CRF) and cognition in a large sample of older adults, and to examine clinical and demographic factors that might moderate these associations.<h4>Methods</h4>CRF was measured with a graded exercise test performed on a motorised treadmill. A confirmatory factor analysis was conducted using data from a comprehensive neuropsychological battery to obtain latent factors reflecting core cognitive domains. Linear regression models evaluated the association between CRF and each of the cognitive composites, and potential moderators including demographic factors (age, sex, education), apolipoprotein E ε4 (<i>APOE4</i>) carriage, beta-blocker use and components of maximal effort criteria during CRF testing.<h4>Results</hBritish journal of sports medicineCardiorespiratory fitness is associated with cognitive function in late adulthood: baseline findings from the IGNITE study.PMC11790366K23 MH129882R35 AG072307R01 AG053952Jakicic JMHarrison RWan LLesnovskaya AHuang HGrove GRomano ADrake JHillman CHBurns JMRipperger HSKamboh MIKramer AErickson KIVidoni EDOberlin LEKang CMolina-Hidalgo CAghjayan SMcAuley ECollins AMfalseCardiorespiratory fitness is associated with cognitive function in late adulthood: baseline findings from the IGNITE study.<h4>Objectives</h4>To evaluate the association between cardiorespiratory fitness (CRF) and cognition in a large sample of older adults, and to examine clinical and demographic factors that might moderate these associations.<h4>Methods</h4>CRF was measured with a graded exercise test performed on a motorised treadmill. A confirmatory factor analysis was conducted using data from a comprehensive neuropsychological battery to obtain latent factors reflecting core cognitive domains. Linear regression models evaluated the association between CRF and each of the cognitive composites, and potential moderators including demographic factors (age, sex, education), apolipoprotein E ε4 (<i>APOE4</i>) carriage, beta-blocker use and components of maximal effort criteria during CRF testing.<h4>Results</h2025-01-01T00:00:00Z2025 Feb2026-06-02T20:04:41.63Z2025-04-06T08:34:08.637ZS-EPMC117903663965827610.1136/bjsports-2024-108257