{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kirchhoff A"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","Ministry of Education and Research (BMBF)"],"pagination":["824-853"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11791083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(3)"],"pubmed_abstract":["The cytosolic nucleic acid sensors RIG-I and cGAS induce type-I interferon (IFN)-mediated immune responses to RNA and DNA viruses, respectively. So far no connection between the two cytosolic pathways upstream of IKK-like kinase activation has been investigated. Here, we identify heterogeneous nuclear ribonucleoprotein M (hnRNPM) as a positive regulator of IRF3 phosphorylation and type-I IFN induction downstream of both cGAS and RIG-I. Combining interactome analysis with genome editing, we further uncover the RNA-binding protein ELAV-like protein 1 (ELAVL1; also known as human antigen R, HuR) as an hnRNPM interactor. Depletion of hnRNPM or ELAVL1 impairs type-I IFN induction by herpes simplex virus 1 or Sendai virus. In addition, we show that hnRNPM and ELAVL1 interact with TANK-binding ki"],"journal":["The EMBO journal"],"pubmed_title":["RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I."],"pmcid":["PMC11791083"],"funding_grant_id":["Bo&MeRanG GRK 2168","CRC237 369799452/A11","174793735","01GL2405H","SCHL1930/1-2","322568668","CRC237 369799452/B21","01GM2206C","216372545","388159768","EXC2151 - 390873048","GRK2168 272482170","CRC369 501752319/C06","TRR259 397484323","SFB670","TRR237 - 369799452"],"pubmed_authors":["Lee-Kirsch MA","Ciupka K","Mahlberg J","Gunther C","Bartok E","Kato H","Kummerer BM","Wallerath C","Schmidt FI","Bootz RJ","Christensen MH","Urban C","Geyer M","Schlee-Guimaraes TM","Hunkler C","Piras A","Schlee M","de Regt AK","Herzner AM","Duster R","Leka P","Hartmann G","Kirchhoff A","Grunewald A","Pichlmair A"],"additional_accession":[]},"is_claimable":false,"name":"RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.","description":"The cytosolic nucleic acid sensors RIG-I and cGAS induce type-I interferon (IFN)-mediated immune responses to RNA and DNA viruses, respectively. So far no connection between the two cytosolic pathways upstream of IKK-like kinase activation has been investigated. Here, we identify heterogeneous nuclear ribonucleoprotein M (hnRNPM) as a positive regulator of IRF3 phosphorylation and type-I IFN induction downstream of both cGAS and RIG-I. Combining interactome analysis with genome editing, we further uncover the RNA-binding protein ELAV-like protein 1 (ELAVL1; also known as human antigen R, HuR) as an hnRNPM interactor. Depletion of hnRNPM or ELAVL1 impairs type-I IFN induction by herpes simplex virus 1 or Sendai virus. In addition, we show that hnRNPM and ELAVL1 interact with TANK-binding ki","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T00:54:54.081Z","creation":"2025-04-04T00:54:54.081Z"},"accession":"S-EPMC11791083","cross_references":{"pubmed":["39707025"],"doi":["10.1038/s44318-024-00331-x"]}}