{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Z"],"funding":["Shenzhen Basic Research Program","Guangdong Basic and Applied Basic Research Funds","Shenzhen Hospital, Southern Medical University","National Natural Science Foundation of China","Shanghai Rising-Star Program","National Key Research and Development Program of China"],"pagination":["e2411272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11791973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Accurate detection of tumor margins is essential for successful cancer surgery. While indocyanine green (ICG)-based near-infrared (NIR) fluorescence (FL) surgical navigation enhances the visual identification of tumor margins, its accuracy remains subjective, underscoring the need for quantitative approaches. In this study, a high spatiotemporal fluorescence lifetime (FLT) imaging technology is developed in the second near-infrared window (NIR-II, 1000-1700 nm) for quantitative tumor margin detection, utilizing folate receptor-targeted ICG nanoprobes (FPH-ICG). FPH-ICG exhibits a significantly prolonged NIR-II FLT (750 ± 7 ps vs 260 ± 3 ps) and increased NIR-II FL brightness (FPH-ICG/ICG = 3.8). In vitro and in vivo studies confirm that FPH-ICG specifically targets folate receptor-α (FRα) "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["High Spatiotemporal Near-Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins."],"pmcid":["PMC11791973"],"funding_grant_id":["B2302021","82372022","2023A1515140133","92159304","82227806","2023YFF0714200","2022A1515140102","2023YFF0715200","82102123","82102106","2022A1515140017","23QC1400100","2024A1515030212","E3A1051001","2023A1515010747","JCYJ20230807140819041","82171958"],"pubmed_authors":["Liao J","Hu D","Zheng H","Sheng Z","Chen Z","Bao Z","Chen J","Huang L","Zheng W","Gao D"],"additional_accession":[]},"is_claimable":false,"name":"High Spatiotemporal Near-Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins.","description":"Accurate detection of tumor margins is essential for successful cancer surgery. While indocyanine green (ICG)-based near-infrared (NIR) fluorescence (FL) surgical navigation enhances the visual identification of tumor margins, its accuracy remains subjective, underscoring the need for quantitative approaches. In this study, a high spatiotemporal fluorescence lifetime (FLT) imaging technology is developed in the second near-infrared window (NIR-II, 1000-1700 nm) for quantitative tumor margin detection, utilizing folate receptor-targeted ICG nanoprobes (FPH-ICG). FPH-ICG exhibits a significantly prolonged NIR-II FLT (750 ± 7 ps vs 260 ± 3 ps) and increased NIR-II FL brightness (FPH-ICG/ICG = 3.8). In vitro and in vivo studies confirm that FPH-ICG specifically targets folate receptor-α (FRα) ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-02T14:33:21.494Z","creation":"2025-04-19T06:02:30.406Z"},"accession":"S-EPMC11791973","cross_references":{"pubmed":["39652447"],"doi":["10.1002/advs.202411272"]}}