{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(5)"],"submitter":["Aljuhani A"],"pubmed_abstract":["Considering the widespread availability of certain medicines, there is still a critical need for potent anti-cancer agents. It is owing to numerous negative impacts and non-functionality of current drugs, particularly during the late stages of illness. To accomplish this, the new array of 1,2,3-triazole-benzothiazole molecular conjugates tethering hydrazone/thiosemicarbazone linkage 8a-l have been successfully synthesized <i>via</i> the efficient copper-catalyzed 1,3-dipolar cycloaddition of the appropriate un/substituted benzothiazole azides 4a-c with several <i>O</i>-propargylated benzylidene derivatives 7a-d. The newly established 1,2,3-triazole structural hybrids were thoroughly characterized using appropriate spectroscopic techniques (IR, <sup>1</sup>H, <sup>13</sup>C-NMR & CHN analys"],"journal":["RSC advances"],"pagination":["3570-3591"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11792500"],"repository":["biostudies-literature"],"pubmed_title":["Discovery of new benzothiazole-1,2,3-triazole hybrid-based hydrazone/thiosemicarbazone derivatives as potent EGFR inhibitors with cytotoxicity against cancer."],"pmcid":["PMC11792500"],"pubmed_authors":["Aouad MR","Rezki N","Alsehli M","Bardaweel SK","Aljuhani A","Darwish KM","Nafie MS","Albujuq NR","Alraqa SY"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of new benzothiazole-1,2,3-triazole hybrid-based hydrazone/thiosemicarbazone derivatives as potent EGFR inhibitors with cytotoxicity against cancer.","description":"Considering the widespread availability of certain medicines, there is still a critical need for potent anti-cancer agents. It is owing to numerous negative impacts and non-functionality of current drugs, particularly during the late stages of illness. To accomplish this, the new array of 1,2,3-triazole-benzothiazole molecular conjugates tethering hydrazone/thiosemicarbazone linkage 8a-l have been successfully synthesized <i>via</i> the efficient copper-catalyzed 1,3-dipolar cycloaddition of the appropriate un/substituted benzothiazole azides 4a-c with several <i>O</i>-propargylated benzylidene derivatives 7a-d. The newly established 1,2,3-triazole structural hybrids were thoroughly characterized using appropriate spectroscopic techniques (IR, <sup>1</sup>H, <sup>13</sup>C-NMR & CHN analys","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T02:00:36.102Z","creation":"2025-04-06T22:27:08.649Z"},"accession":"S-EPMC11792500","cross_references":{"pubmed":["39906636"],"doi":["10.1039/d4ra07540d"]}}