{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Velz J"],"funding":["European Research Council"],"pagination":["1364"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11794601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Medulloblastoma is the most frequent malignant primary brain tumor in children. Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches are needed. Here, we present an atlas of naturally presented T cell antigens in medulloblastoma. We map the human leukocyte antigen (HLA)-presented peptidomes of 28 tumors and perform comparative immunopeptidome profiling against an in-house benign database. Medulloblastoma is shown to be a rich source of tumor-associated antigens, naturally presented on HLA class I and II molecules. Remarkably, most tumor-associated peptides and proteins are subgroup-specific, whereas shared presentation among all subgroups of medulloblastoma (WNT, SHH, Grou"],"journal":["Nature communications"],"pubmed_title":["Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics."],"pmcid":["PMC11794601"],"funding_grant_id":["339842"],"pubmed_authors":["Kapolou K","Weller M","Velz J","Rohrig A","Bozinov O","Craveiro RB","Frey BM","Grotzer M","Reinhard H","Weiss T","Kowalewski DJ","Eyrich M","Silginer M","Krayenbuhl N","Neidert MC","Walz JS","Medici G","Messing-Junger M","Freudenmann LK","Gauder M","Westphal M","Zeitlberger AM","Regli L","Scheid J","Wirsching HG","Rammensee HG","Ghasemi DR","Patterson AB","Sahm F","Nahnsen S","Dubbelaar M","Mohme M","Lamszus K","Rushing EJ","Beccaria K","Roth P","Sill M"],"additional_accession":[]},"is_claimable":false,"name":"Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics.","description":"Medulloblastoma is the most frequent malignant primary brain tumor in children. Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches are needed. Here, we present an atlas of naturally presented T cell antigens in medulloblastoma. We map the human leukocyte antigen (HLA)-presented peptidomes of 28 tumors and perform comparative immunopeptidome profiling against an in-house benign database. Medulloblastoma is shown to be a rich source of tumor-associated antigens, naturally presented on HLA class I and II molecules. Remarkably, most tumor-associated peptides and proteins are subgroup-specific, whereas shared presentation among all subgroups of medulloblastoma (WNT, SHH, Grou","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T07:26:39.679Z","creation":"2025-04-04T07:26:39.679Z"},"accession":"S-EPMC11794601","cross_references":{"pubmed":["39904979"],"doi":["10.1038/s41467-025-56268-0"]}}