biostudies-literatureUnknown15(1)Pupillo EThe COVIVAX study assessed the association between COVID-19 vaccination and the risk of common neurological disorders in a multicenter case-control design. Vaccination exposure was compared between individuals with a first diagnosis of a neurological disorder (cases) and age- and sex-matched controls. A total of 624 participants were enrolled, and after random 1:1 matching 265 cases and 265 matched controls (total 530 participants) were included in the analyses. The most frequent neurological diagnosis in cases were stroke (60.4%), multiple sclerosis (11.3%) and seizures (6.4%). The proportion of vaccinated participants was 72.1% among cases and 79.6% among controls. A protective role of vaccination on the risk of developing a new neurological disorder was detected in the unadjusted analysScientific reports4179https://www.ebi.ac.uk/biostudies/studies/S-EPMC11794632biostudies-literatureMulticentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX).PMC11794632Primiano GFerrarese CBorghi ACalabresi PScaccabarozzi CKiferle LBeretta STedeschi GContardi SAvino GGallo APilotto AMainini GMelisi RDBeghi ECristillo VValenti RBianchi EPupillo EPercetti Md'Ambrosio AZini AGipponi SPedrazzini FAGiglio ASchilke EDBisecco AArici DPadovani AMorotti Colleoni CFrisullo GBasilico PSalmaggi AfalseMulticentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX).The COVIVAX study assessed the association between COVID-19 vaccination and the risk of common neurological disorders in a multicenter case-control design. Vaccination exposure was compared between individuals with a first diagnosis of a neurological disorder (cases) and age- and sex-matched controls. A total of 624 participants were enrolled, and after random 1:1 matching 265 cases and 265 matched controls (total 530 participants) were included in the analyses. The most frequent neurological diagnosis in cases were stroke (60.4%), multiple sclerosis (11.3%) and seizures (6.4%). The proportion of vaccinated participants was 72.1% among cases and 79.6% among controls. A protective role of vaccination on the risk of developing a new neurological disorder was detected in the unadjusted analys2025-01-01T00:00:00Z2025 Feb2025-07-26T03:06:56.6Z2025-04-06T10:12:45.155ZS-EPMC117946323990522110.1038/s41598-025-88837-0