{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35(2)"],"submitter":["Papenberg G"],"funding":["Alexander von Humboldt Research","Umeå University","Swedish Brain Power","Västerbotten County Council","Innovation Fund of the Max Planck Society","Knut and Alice Wallenberg Foundation","Torsten and Ragnar Söderberg Foundation","Jochnick Foundation","Umeå University-Karolinska Institute Strategic Neuroscience Program","Swedish Brain Foundation","Swedish Research Council","2010 Leibniz Research Award from the German Research Foundation"],"pubmed_abstract":["Although age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline). Greater decline in D2/3 dopamine receptor availability in working memory-relevant regions (caudate, middle frontal cortex, hippocampus) was related to greater decline in working memory"],"journal":["Cerebral cortex (New York, N.Y. : 1991)"],"pagination":["bhae481"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11795306"],"repository":["biostudies-literature"],"pubmed_title":["Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years."],"pmcid":["PMC11795306"],"pubmed_authors":["Axelsson J","Nyberg L","Salami A","Papenberg G","Wahlin A","Lindenberger U","Backman L","Karalija N","Andersson M","Johansson J","Garrett DD","Riklund K"],"additional_accession":[]},"is_claimable":false,"name":"Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years.","description":"Although age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline). Greater decline in D2/3 dopamine receptor availability in working memory-relevant regions (caudate, middle frontal cortex, hippocampus) was related to greater decline in working memory","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T07:26:17.727Z","creation":"2025-04-04T07:26:17.727Z"},"accession":"S-EPMC11795306","cross_references":{"pubmed":["39756432"],"doi":["10.1093/cercor/bhae481"]}}