biostudies-literatureUnknown35(2)Papenberg GAlexander von Humboldt ResearchUmeå UniversitySwedish Brain PowerVästerbotten County CouncilInnovation Fund of the Max Planck SocietyKnut and Alice Wallenberg FoundationTorsten and Ragnar Söderberg FoundationJochnick FoundationUmeå University-Karolinska Institute Strategic Neuroscience ProgramSwedish Brain FoundationSwedish Research Council2010 Leibniz Research Award from the German Research FoundationAlthough age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline). Greater decline in D2/3 dopamine receptor availability in working memory-relevant regions (caudate, middle frontal cortex, hippocampus) was related to greater decline in working memoryCerebral cortex (New York, N.Y. : 1991)bhae481https://www.ebi.ac.uk/biostudies/studies/S-EPMC11795306biostudies-literatureAging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years.PMC11795306Axelsson JNyberg LSalami APapenberg GWahlin ALindenberger UBackman LKaralija NAndersson MJohansson JGarrett DDRiklund KfalseAging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years.Although age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline). Greater decline in D2/3 dopamine receptor availability in working memory-relevant regions (caudate, middle frontal cortex, hippocampus) was related to greater decline in working memory2025-01-01T00:00:00Z2025 Feb2025-04-04T07:26:17.727Z2025-04-04T07:26:17.727ZS-EPMC117953063975643210.1093/cercor/bhae481