{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["55"],"submitter":["Moya A"],"pubmed_abstract":["<h4>Background</h4>Cardiac transthyretin (ATTR) amyloidosis is an often underdiagnosed and potentially fatal disorder associated with poor survival. The National Amyloidosis Centre (NAC) staging system, based on NT-proBNP level and eGFR value, discriminates patients according to survival rates. However, NAC stage II involves a heterogenous group of patients with variable prognosis. This retrospective single-center study was set up to explore the potential role of myocardial work (MW) analysis to enhance risk stratification of ATTR patients prior to therapy.<h4>Methods and results</h4>37 patients diagnosed with ATTR between March 2021 and August 2023 were included. Baseline NT-proBNP and eGFR values were collected and LVEF, GLS and MW parameters were obtained from stored echocardiographic i"],"journal":["International journal of cardiology. Heart & vasculature"],"pagination":["101551"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11795697"],"repository":["biostudies-literature"],"pubmed_title":["Myocardial work assessment to improve baseline risk stratification in patients with transthyretin amyloidosis."],"pmcid":["PMC11795697"],"pubmed_authors":["Bartunek J","Goethals M","Moya A","Beles M","Heggermont WA","Vanderheyden M","Kelen de Oliveira E","Buytaert D","Dierckx R","Dauw J"],"additional_accession":[]},"is_claimable":false,"name":"Myocardial work assessment to improve baseline risk stratification in patients with transthyretin amyloidosis.","description":"<h4>Background</h4>Cardiac transthyretin (ATTR) amyloidosis is an often underdiagnosed and potentially fatal disorder associated with poor survival. The National Amyloidosis Centre (NAC) staging system, based on NT-proBNP level and eGFR value, discriminates patients according to survival rates. However, NAC stage II involves a heterogenous group of patients with variable prognosis. This retrospective single-center study was set up to explore the potential role of myocardial work (MW) analysis to enhance risk stratification of ATTR patients prior to therapy.<h4>Methods and results</h4>37 patients diagnosed with ATTR between March 2021 and August 2023 were included. Baseline NT-proBNP and eGFR values were collected and LVEF, GLS and MW parameters were obtained from stored echocardiographic i","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T07:26:42.365Z","creation":"2025-04-04T07:26:42.365Z"},"accession":"S-EPMC11795697","cross_references":{"pubmed":["39911619"],"doi":["10.1016/j.ijcha.2024.101551"]}}