biostudies-literatureUnknown55Moya A<h4>Background</h4>Cardiac transthyretin (ATTR) amyloidosis is an often underdiagnosed and potentially fatal disorder associated with poor survival. The National Amyloidosis Centre (NAC) staging system, based on NT-proBNP level and eGFR value, discriminates patients according to survival rates. However, NAC stage II involves a heterogenous group of patients with variable prognosis. This retrospective single-center study was set up to explore the potential role of myocardial work (MW) analysis to enhance risk stratification of ATTR patients prior to therapy.<h4>Methods and results</h4>37 patients diagnosed with ATTR between March 2021 and August 2023 were included. Baseline NT-proBNP and eGFR values were collected and LVEF, GLS and MW parameters were obtained from stored echocardiographic iInternational journal of cardiology. Heart & vasculature101551https://www.ebi.ac.uk/biostudies/studies/S-EPMC11795697biostudies-literatureMyocardial work assessment to improve baseline risk stratification in patients with transthyretin amyloidosis.PMC11795697Bartunek JGoethals MMoya ABeles MHeggermont WAVanderheyden MKelen de Oliveira EBuytaert DDierckx RDauw JfalseMyocardial work assessment to improve baseline risk stratification in patients with transthyretin amyloidosis.<h4>Background</h4>Cardiac transthyretin (ATTR) amyloidosis is an often underdiagnosed and potentially fatal disorder associated with poor survival. The National Amyloidosis Centre (NAC) staging system, based on NT-proBNP level and eGFR value, discriminates patients according to survival rates. However, NAC stage II involves a heterogenous group of patients with variable prognosis. This retrospective single-center study was set up to explore the potential role of myocardial work (MW) analysis to enhance risk stratification of ATTR patients prior to therapy.<h4>Methods and results</h4>37 patients diagnosed with ATTR between March 2021 and August 2023 were included. Baseline NT-proBNP and eGFR values were collected and LVEF, GLS and MW parameters were obtained from stored echocardiographic i2024-01-01T00:00:00Z2024 Dec2025-04-04T07:26:42.365Z2025-04-04T07:26:42.365ZS-EPMC117956973991161910.1016/j.ijcha.2024.101551