biostudies-literatureFan LZhejiang Province Traditional Chinese Medicine Science and Technology ProjectNational Natural Science Foundation of China38https://www.ebi.ac.uk/biostudies/studies/S-EPMC11796166biostudies-literatureUnknown24(1)<h4>Background</h4>This study aimed to analyse the relationship of the blood lipid profile and interleukin-6 (IL-6) with osteoporosis and osteopenia and to explore the predictive value of the combined application of these biomarkers in osteoporosis and osteopenia.<h4>Methods</h4>Data from 276 patients treated in the orthopaedics department were retrospectively analysed. Their general information was collected, and the relationships among the blood lipid profile, IL-6 with bone turnover markers, and bone mineral density (BMD) were analysed. Patients were categorized based on their T scores for intergroup comparisons. Finally, the diagnostic efficiency of lipid metabolism markers and IL-6 for osteoporosis and osteopenia was assessed using receiver operating characteristic (ROC) curves.<h4>ReLipids in health and diseaseThe diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia.PMC117961662023ZL46181873128Yang YChen JChen ZZhang YFan LChen CfalseThe diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia.<h4>Background</h4>This study aimed to analyse the relationship of the blood lipid profile and interleukin-6 (IL-6) with osteoporosis and osteopenia and to explore the predictive value of the combined application of these biomarkers in osteoporosis and osteopenia.<h4>Methods</h4>Data from 276 patients treated in the orthopaedics department were retrospectively analysed. Their general information was collected, and the relationships among the blood lipid profile, IL-6 with bone turnover markers, and bone mineral density (BMD) were analysed. Patients were categorized based on their T scores for intergroup comparisons. Finally, the diagnostic efficiency of lipid metabolism markers and IL-6 for osteoporosis and osteopenia was assessed using receiver operating characteristic (ROC) curves.<h4>Re2025-01-01T00:00:00Z2025 Feb2025-04-18T13:02:05.208Z2025-04-06T22:26:11.716ZS-EPMC117961663991053910.1186/s12944-025-02456-2