{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Uriot O"],"pubmed_abstract":["Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder, with diarrhea-predominant IBS (IBS-D) as the most frequent subtype. The implication of gut microbiota in the disease's etiology is not fully understood. <i>In vitro</i> gut systems can offer a great alternative to <i>in vivo</i> assays in preclinical studies, but no model reproducing IBS-related dysbiotic microbiota has been developed. Thanks to a large literature review, a new Mucosal ARtifical COLon (M-ARCOL) adapted to IBS-D physicochemical and nutritional conditions was set-up. To validate the model and further exploit its potential in a mechanistic study, <i>in vitro</i> fermentations were performed using bioreactors inoculated with stools from healthy individuals (<i>n</i> = 4) or IBS-D patients (<i>n</i> ="],"journal":["Bioengineered"],"pagination":["2458362"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11796540"],"repository":["biostudies-literature"],"pubmed_title":["Gut microbial dysbiosis associated to diarrheic irritable bowel syndrome can be efficiently simulated in the Mucosal ARtificial COLon (M-ARCOL)."],"pmcid":["PMC11796540"],"pubmed_authors":["Scanzi J","Dapoigny M","Langella P","Deschamps C","Durif C","Kerckhove N","Etienne-Mesmin L","Denis S","Brun M","Fournier E","Duale C","Uriot O","Alric M","Stephanie BD"],"additional_accession":[]},"is_claimable":false,"name":"Gut microbial dysbiosis associated to diarrheic irritable bowel syndrome can be efficiently simulated in the Mucosal ARtificial COLon (M-ARCOL).","description":"Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder, with diarrhea-predominant IBS (IBS-D) as the most frequent subtype. The implication of gut microbiota in the disease's etiology is not fully understood. <i>In vitro</i> gut systems can offer a great alternative to <i>in vivo</i> assays in preclinical studies, but no model reproducing IBS-related dysbiotic microbiota has been developed. Thanks to a large literature review, a new Mucosal ARtifical COLon (M-ARCOL) adapted to IBS-D physicochemical and nutritional conditions was set-up. To validate the model and further exploit its potential in a mechanistic study, <i>in vitro</i> fermentations were performed using bioreactors inoculated with stools from healthy individuals (<i>n</i> = 4) or IBS-D patients (<i>n</i> =","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2025-04-04T07:26:20.853Z","creation":"2025-04-04T07:26:20.853Z"},"accession":"S-EPMC11796540","cross_references":{"pubmed":["39902883"],"doi":["10.1080/21655979.2025.2458362"]}}