{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["149(17)"],"submitter":["Dai Y"],"pubmed_abstract":["<h4>Background</h4>Observational studies have revealed relationships between circulating vitamin D concentrations and the risk of different types of cancer, although the potential causal relationship remains controversial. This study aims to investigate the presence of a causal relationship between circulating vitamin D concentrations and the risk of different types of cancer.<h4>Methods</h4>Summary statistics from corresponding genome-wide association studies (GWASs) were used to investigate the causal relationship between circulating vitamin D concentrations and the risk of 14 cancers. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighting (IVW) as the primary method was performed. Additionally, the results were verified using four other methods, including MR"],"journal":["Journal of cancer research and clinical oncology"],"pagination":["15457-15467"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11796945"],"repository":["biostudies-literature"],"pubmed_title":["Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study."],"pmcid":["PMC11796945"],"pubmed_authors":["Pu Y","Jiang R","Chen Y","Dai Y"],"additional_accession":[]},"is_claimable":false,"name":"Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study.","description":"<h4>Background</h4>Observational studies have revealed relationships between circulating vitamin D concentrations and the risk of different types of cancer, although the potential causal relationship remains controversial. This study aims to investigate the presence of a causal relationship between circulating vitamin D concentrations and the risk of different types of cancer.<h4>Methods</h4>Summary statistics from corresponding genome-wide association studies (GWASs) were used to investigate the causal relationship between circulating vitamin D concentrations and the risk of 14 cancers. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighting (IVW) as the primary method was performed. Additionally, the results were verified using four other methods, including MR","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-08-16T03:05:44.993Z","creation":"2025-08-16T03:05:44.993Z"},"accession":"S-EPMC11796945","cross_references":{"pubmed":["37642723"],"doi":["10.1007/s00432-023-05322-9"]}}