biostudies-literatureUnknown149(17)Dai Y<h4>Background</h4>Observational studies have revealed relationships between circulating vitamin D concentrations and the risk of different types of cancer, although the potential causal relationship remains controversial. This study aims to investigate the presence of a causal relationship between circulating vitamin D concentrations and the risk of different types of cancer.<h4>Methods</h4>Summary statistics from corresponding genome-wide association studies (GWASs) were used to investigate the causal relationship between circulating vitamin D concentrations and the risk of 14 cancers. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighting (IVW) as the primary method was performed. Additionally, the results were verified using four other methods, including MRJournal of cancer research and clinical oncology15457-15467https://www.ebi.ac.uk/biostudies/studies/S-EPMC11796945biostudies-literatureCirculating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study.PMC11796945Pu YJiang RChen YDai YfalseCirculating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study.<h4>Background</h4>Observational studies have revealed relationships between circulating vitamin D concentrations and the risk of different types of cancer, although the potential causal relationship remains controversial. This study aims to investigate the presence of a causal relationship between circulating vitamin D concentrations and the risk of different types of cancer.<h4>Methods</h4>Summary statistics from corresponding genome-wide association studies (GWASs) were used to investigate the causal relationship between circulating vitamin D concentrations and the risk of 14 cancers. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighting (IVW) as the primary method was performed. Additionally, the results were verified using four other methods, including MR2023-01-01T00:00:00Z2023 Nov2025-08-16T03:05:44.993Z2025-08-16T03:05:44.993ZS-EPMC117969453764272310.1007/s00432-023-05322-9