{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lv L"],"funding":["Shandong Provincial Natural Science Foundation","Academic Promotion Programme of Shandong First Medical University","National Natural Science Foundation","China Postdoctoral Science Foundation","Key Research and Development Program of Shandong Province","Shandong Provincial Engineering Research Center of Lymphoma","Taishan Scholars Program of Shandong Province","Translational Research Grant of NCRCH"],"pagination":["12677-12690"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11797697"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(14)"],"pubmed_abstract":["<h4>Purpose</h4>Emerging evidence suggests that pyroptosis plays an essential role in the development and progression of multiple cancers. However, the role of pyroptosis remains elusive in diffuse large B-cell lymphoma (DLBCL).<h4>Methods</h4>The expression profile data of DLBCL and normal samples of pyroptosis-related genes (PRGs) were analyzed, and the clinical characteristics of DLBCL patients were further investigated. A prognostic model was established using LASSO-Cox regression analysis. The expression of these PRGs was validated by qRT-PCR in DLBCL cell lines. Cell proliferation assay and flow cytometry were utilized to explore the impact of pyroptosis inhibitor (disulfiram, DSF) combined with PD1/PD-L1 inhibitor (BMS1166) on DLBCL cell proliferation.<h4>Results</h4>Most PRGs were "],"journal":["Journal of cancer research and clinical oncology"],"pubmed_title":["Identification of pyroptosis-related signature and development of a novel prognostic model in diffuse large B-cell lymphoma."],"pmcid":["PMC11797697"],"funding_grant_id":["No.2021WWB02","No.2020ZKMB01","ZR2021YQ51","No. 2021T1404223","No.2018CXGC1213","No. 2019QL018","No.82070203, No.81770210","No.82170189, No.81800194"],"pubmed_authors":["Lv L","Kong R","Zhang Y","Wang C","Wang X","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Identification of pyroptosis-related signature and development of a novel prognostic model in diffuse large B-cell lymphoma.","description":"<h4>Purpose</h4>Emerging evidence suggests that pyroptosis plays an essential role in the development and progression of multiple cancers. However, the role of pyroptosis remains elusive in diffuse large B-cell lymphoma (DLBCL).<h4>Methods</h4>The expression profile data of DLBCL and normal samples of pyroptosis-related genes (PRGs) were analyzed, and the clinical characteristics of DLBCL patients were further investigated. A prognostic model was established using LASSO-Cox regression analysis. The expression of these PRGs was validated by qRT-PCR in DLBCL cell lines. Cell proliferation assay and flow cytometry were utilized to explore the impact of pyroptosis inhibitor (disulfiram, DSF) combined with PD1/PD-L1 inhibitor (BMS1166) on DLBCL cell proliferation.<h4>Results</h4>Most PRGs were ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-03-27T16:57:58.349Z","creation":"2025-09-01T03:05:18.753Z"},"accession":"S-EPMC11797697","cross_references":{"pubmed":["37452851"],"doi":["10.1007/s00432-023-05018-0"]}}