{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Houweling M"],"funding":["Brain Tumour Charity","The Brain Tumour Charity","KWF Kankerbestrijding"],"pagination":["297-305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11798055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(1)"],"pubmed_abstract":["<h4>Introduction</h4>Glioblastoma (GBM) is an incurable cancer type. New therapeutic options are investigated, including targeting the mitogen-activated protein kinase (MAPK) pathway using MEK inhibitors as radio-sensitizers. In this study, we investigated whether MEK inhibition via PD0325901 leads to radio-sensitization in experimental in vitro and in vivo models of GBM.<h4>Materials and methods</h4>In vitro, GBM8 multicellular spheroids were irradiated with 3 fractions of 2 Gy, during 5 consecutive days of incubation with either PD0325901 or MEK-162. In vivo, we combined PD0325901 with radiotherapy in the GBM8 orthotopic mouse model, tumor growth was measured weekly by bioluminescence imaging and overall survival and toxicity were assessed.<h4>Results</h4>Regrowth and viability of sphero"],"journal":["Journal of cancer research and clinical oncology"],"pubmed_title":["Radio-sensitizing effect of MEK inhibition in glioblastoma in vitro and in vivo."],"pmcid":["PMC11798055"],"funding_grant_id":["488097","KWF 4874","GN-000429","11038"],"pubmed_authors":["Heukelom S","Westerman BA","Wurdinger T","Noske D","Houweling M","Verheul H","Abdul UK","Lagerweij T","Brahm C","Koken PW","Sminia P","Honeywell R","Peters GJ","Wedekind LE"],"additional_accession":[]},"is_claimable":false,"name":"Radio-sensitizing effect of MEK inhibition in glioblastoma in vitro and in vivo.","description":"<h4>Introduction</h4>Glioblastoma (GBM) is an incurable cancer type. New therapeutic options are investigated, including targeting the mitogen-activated protein kinase (MAPK) pathway using MEK inhibitors as radio-sensitizers. In this study, we investigated whether MEK inhibition via PD0325901 leads to radio-sensitization in experimental in vitro and in vivo models of GBM.<h4>Materials and methods</h4>In vitro, GBM8 multicellular spheroids were irradiated with 3 fractions of 2 Gy, during 5 consecutive days of incubation with either PD0325901 or MEK-162. In vivo, we combined PD0325901 with radiotherapy in the GBM8 orthotopic mouse model, tumor growth was measured weekly by bioluminescence imaging and overall survival and toxicity were assessed.<h4>Results</h4>Regrowth and viability of sphero","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-03-27T15:50:09.482Z","creation":"2025-08-27T03:06:40.443Z"},"accession":"S-EPMC11798055","cross_references":{"pubmed":["36451044"],"doi":["10.1007/s00432-022-04483-3"]}}