biostudies-literatureUnknown114(3)Chowdhury SRCanadian Blood ServicesEinstein Foundation BerlinEinstein Stiftung BerlinCanadian Institutes of Health ResearchCIHR<h4>Objectives</h4>Evidence-based protocols for managing bleeding emergencies in patients with immune thrombocytopenia (ITP) are lacking. We conducted a systematic review of treatments for critical bleeding in patients with ITP.<h4>Methods</h4>We included all study designs and extracted data in aggregate or individually for patients who received one or more interventions and for whom any of the following outcomes were reported: platelet count response, bleeding, disability, or death.<h4>Results</h4>We identified 49 eligible studies reporting 112 critical bleed patients with ITP, including 66 children (median age, 10 years), 36 adults (median age, 41.5 years), and 10 patients with unreported age. Patients received corticosteroids (n = 67), IVIG (n = 49), platelet transfusions (n = 41), TPO-European journal of haematology458-468https://www.ebi.ac.uk/biostudies/studies/S-EPMC11798764biostudies-literatureTreatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review.PMC11798764Strachan GArnold DMGill DFein SCouban RChowdhury SREisa KManski CGuyatt GChowdhury MRPorter SCooper NBeck CEYan JWSirotich EPruitt BPaynter DAgarwal AMahamad SWen AKelton JGKang MO'Connor C-DiRaimo JMModi DCuker AGrace RFZeraatkar DThabane LLeong RPallapothu SXu Ede Wit KCharness JNazaryan HKwon HDookie JBreakey VRHassan ZPai MRathod PWebert KESiddiqui ILiu BVenier LMShafiee AfalseTreatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review.<h4>Objectives</h4>Evidence-based protocols for managing bleeding emergencies in patients with immune thrombocytopenia (ITP) are lacking. We conducted a systematic review of treatments for critical bleeding in patients with ITP.<h4>Methods</h4>We included all study designs and extracted data in aggregate or individually for patients who received one or more interventions and for whom any of the following outcomes were reported: platelet count response, bleeding, disability, or death.<h4>Results</h4>We identified 49 eligible studies reporting 112 critical bleed patients with ITP, including 66 children (median age, 10 years), 36 adults (median age, 41.5 years), and 10 patients with unreported age. Patients received corticosteroids (n = 67), IVIG (n = 49), platelet transfusions (n = 41), TPO-2025-01-01T00:00:00Z2025 Mar2025-04-26T01:43:05.983Z2025-04-06T10:13:24.404ZS-EPMC117987643955226410.1111/ejh.14351