{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Siwek M"],"pubmed_abstract":["<h4>Introduction</h4>Early research on the pharmacotherapy for major depressive disorder (MDD) has largely focused on symptomatic improvements, whereas this focus has shifted to functioning and quality of life in recent years. Studies have confirmed that antidepressants generally improve the functional outcomes in MDD, but very few works have compared the efficacies of specific drugs. The present work aims to compare the impacts of trazodone once-a-day extended-release (XR) vs selective serotonin reuptake inhibitors (SSRIs) on the health status and quality of life in MDD.<h4>Methods</h4>Data were gathered from 180 subjects through a naturalistic observation study of trazodone effectiveness in depression (TED) and analyzed. The TED study participants received trazodone XR of SSRIs in flexib"],"journal":["Frontiers in pharmacology"],"pagination":["1525498"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11798982"],"repository":["biostudies-literature"],"pubmed_title":["Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder."],"pmcid":["PMC11798982"],"pubmed_authors":["Dudek D","Chrobak AA","Krupa AJ","Juryk A","Siwek M","Gorostowicz A"],"additional_accession":[]},"is_claimable":false,"name":"Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder.","description":"<h4>Introduction</h4>Early research on the pharmacotherapy for major depressive disorder (MDD) has largely focused on symptomatic improvements, whereas this focus has shifted to functioning and quality of life in recent years. Studies have confirmed that antidepressants generally improve the functional outcomes in MDD, but very few works have compared the efficacies of specific drugs. The present work aims to compare the impacts of trazodone once-a-day extended-release (XR) vs selective serotonin reuptake inhibitors (SSRIs) on the health status and quality of life in MDD.<h4>Methods</h4>Data were gathered from 180 subjects through a naturalistic observation study of trazodone effectiveness in depression (TED) and analyzed. The TED study participants received trazodone XR of SSRIs in flexib","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-26T01:37:22.332Z","creation":"2025-04-06T10:15:30.741Z"},"accession":"S-EPMC11798982","cross_references":{"pubmed":["39917327"],"doi":["10.3389/fphar.2024.1525498"]}}