biostudies-literatureUnknown6(1)Iino T<h4>Background</h4>A pilot clinical study of a Tax peptide-pulsed dendritic cell (DC) vaccine for adult T-cell leukaemia/lymphoma (ATL) indicated favourable clinical outcomes.<h4>Methods</h4>We investigated its anti-tumour effect by T cell receptor (TCR) repertoire analysis in samples from an enrolled ATL patient who achieved a 10-year complete remission after DC vaccination.<h4>Results</h4>In this patient, the dominant residual ATL clones that had persisted following previous treatment entirely disappeared within 3 years after DC vaccination. Additionally, the DC vaccine restored TCR repertoire diversity of normal T cells and newly induced functional Tax-specific CD8⁺ T cell clones.<h4>Conclusions</h4>The recovery of normal T cell immunity mediated by the DC vaccine may contribEJHaeme1072https://www.ebi.ac.uk/biostudies/studies/S-EPMC11800367biostudies-literatureElimination of residual adult T-cell leukaemia clones by Tax-targeted dendritic cell vaccine.PMC11800367Matsutani TKannagi MHasegawa AIino TSuehiro YAkashi KfalseElimination of residual adult T-cell leukaemia clones by Tax-targeted dendritic cell vaccine.<h4>Background</h4>A pilot clinical study of a Tax peptide-pulsed dendritic cell (DC) vaccine for adult T-cell leukaemia/lymphoma (ATL) indicated favourable clinical outcomes.<h4>Methods</h4>We investigated its anti-tumour effect by T cell receptor (TCR) repertoire analysis in samples from an enrolled ATL patient who achieved a 10-year complete remission after DC vaccination.<h4>Results</h4>In this patient, the dominant residual ATL clones that had persisted following previous treatment entirely disappeared within 3 years after DC vaccination. Additionally, the DC vaccine restored TCR repertoire diversity of normal T cells and newly induced functional Tax-specific CD8⁺ T cell clones.<h4>Conclusions</h4>The recovery of normal T cell immunity mediated by the DC vaccine may contrib2025-01-01T00:00:00Z2025 Feb2025-04-04T23:59:38.532Z2025-04-04T23:59:38.532ZS-EPMC118003673991735710.1002/jha2.1072