biostudies-literatureUnknown29(1)Marco DN<h4>Background</h4>Time to positivity (TTP) and differential TTP (DTP) emerge as diagnostic and prognostic tools for bloodstream infections (BSI) though specific cut-off values need to be determined for each pathogen. Pseudomonas aeruginosa BSI (PAE-BSI) is of critical concern, particularly in immunocompromised patients, due to high mortality rates. Catheter-related infections are a common cause, necessitating rapid and accurate diagnostic tools for effective management (source-control).<h4>Methods</h4>Unicentric retrospective observational study analyzing the diagnostic utility and best cut-off values of time to positivity (TTP) and differential time to positivity (DTP) to identify catheter-related PAE-BSI and the association of TTP with 30-day mortality.<h4>Results</h4>1177 PAE-BSI casesCritical care (London, England)63https://www.ebi.ac.uk/biostudies/studies/S-EPMC11800533biostudies-literatureTime to positivity as a predictor of catheter-related bacteremia and mortality in adults with Pseudomonas aeruginosa bloodstream infection.PMC11800533Anguera SMonzo-Gallo PBrey MVerdejo MAMartinez JADel Rio AChumbita MPuerta-Alcalde PCasals-Pascual CHernandez-Meneses MCuervo GSoriano APitart CAiello TFHerrera SMarco DNMorata LCardozo CEspasa MMensa JSempere AGarcia FBodro MGarcia-Vidal CGrafia IfalseTime to positivity as a predictor of catheter-related bacteremia and mortality in adults with Pseudomonas aeruginosa bloodstream infection.<h4>Background</h4>Time to positivity (TTP) and differential TTP (DTP) emerge as diagnostic and prognostic tools for bloodstream infections (BSI) though specific cut-off values need to be determined for each pathogen. Pseudomonas aeruginosa BSI (PAE-BSI) is of critical concern, particularly in immunocompromised patients, due to high mortality rates. Catheter-related infections are a common cause, necessitating rapid and accurate diagnostic tools for effective management (source-control).<h4>Methods</h4>Unicentric retrospective observational study analyzing the diagnostic utility and best cut-off values of time to positivity (TTP) and differential time to positivity (DTP) to identify catheter-related PAE-BSI and the association of TTP with 30-day mortality.<h4>Results</h4>1177 PAE-BSI cases2025-01-01T00:00:00Z2025 Feb2025-04-21T15:56:02.88Z2025-04-21T15:56:02.88ZS-EPMC118005333991066010.1186/s13054-025-05292-z