biostudies-literatureDing SLeading Talents Program of Zhejiang Province59https://www.ebi.ac.uk/biostudies/studies/S-EPMC11800640biostudies-literatureUnknown25(1)<h4>Background</h4>Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations.<h4>Methods</h4>Ten healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups. Vital signs and blood indices were meticulously monitored. The integrity of heparin coatings and thrombosis in the ECMO system were assessed at indicated time points, followed by histopathological analysis.<h4>Results</h4>All ten sheep survived to their planned endpoints underBMC anesthesiologyApplication of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations.PMC118006402024C03185Liu ZDing SChen JTeng GHuang MLin HWu YLiang QfalseApplication of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations.<h4>Background</h4>Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations.<h4>Methods</h4>Ten healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups. Vital signs and blood indices were meticulously monitored. The integrity of heparin coatings and thrombosis in the ECMO system were assessed at indicated time points, followed by histopathological analysis.<h4>Results</h4>All ten sheep survived to their planned endpoints under2025-01-01T00:00:00Z2025 Feb2025-04-04T23:59:21.846Z2025-04-04T23:59:21.846ZS-EPMC118006403991571410.1186/s12871-025-02930-5