{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(2)"],"submitter":["Chen Y"],"pubmed_abstract":["Despite the availability of various treatment options, glioblastoma (GBM) remains an extremely aggressive form of glioma with a poor prognosis. In recent studies, regulatory cell death (RCD) has been identified as an effective mechanism to suppress glioma. Cuproptosis, caused by intracellular copper, is a novel RCD process that affects chemotherapy efficacy and glioma progression; however, the precise function of cuproptosis-related lncRNAs (CRLs) and cuproptosis-related genes (CRGs) in GBM remains uncertain. To determine whether CRLs and CRGs have prognostic significance, a GBM cohort in TCGA to build a novel cuproptosis-related risk model. Two high-risk CRLs (AC091182.2, AC005229.4) and their co-expression CRGs (LIPT2, GLS) were identified and verified to constitute an independent progno"],"journal":["PloS one"],"pagination":["e0315927"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11801720"],"repository":["biostudies-literature"],"pubmed_title":["Cuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment."],"pmcid":["PMC11801720"],"pubmed_authors":["Zhang J","Chen Y","Zheng W","Xu H"],"additional_accession":[]},"is_claimable":false,"name":"Cuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment.","description":"Despite the availability of various treatment options, glioblastoma (GBM) remains an extremely aggressive form of glioma with a poor prognosis. In recent studies, regulatory cell death (RCD) has been identified as an effective mechanism to suppress glioma. Cuproptosis, caused by intracellular copper, is a novel RCD process that affects chemotherapy efficacy and glioma progression; however, the precise function of cuproptosis-related lncRNAs (CRLs) and cuproptosis-related genes (CRGs) in GBM remains uncertain. To determine whether CRLs and CRGs have prognostic significance, a GBM cohort in TCGA to build a novel cuproptosis-related risk model. Two high-risk CRLs (AC091182.2, AC005229.4) and their co-expression CRGs (LIPT2, GLS) were identified and verified to constitute an independent progno","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-04T01:37:09.682Z","creation":"2025-04-04T01:37:09.682Z"},"accession":"S-EPMC11801720","cross_references":{"pubmed":["39913607"],"doi":["10.1371/journal.pone.0315927"]}}