biostudies-literatureUnknown20(2)Chen YDespite the availability of various treatment options, glioblastoma (GBM) remains an extremely aggressive form of glioma with a poor prognosis. In recent studies, regulatory cell death (RCD) has been identified as an effective mechanism to suppress glioma. Cuproptosis, caused by intracellular copper, is a novel RCD process that affects chemotherapy efficacy and glioma progression; however, the precise function of cuproptosis-related lncRNAs (CRLs) and cuproptosis-related genes (CRGs) in GBM remains uncertain. To determine whether CRLs and CRGs have prognostic significance, a GBM cohort in TCGA to build a novel cuproptosis-related risk model. Two high-risk CRLs (AC091182.2, AC005229.4) and their co-expression CRGs (LIPT2, GLS) were identified and verified to constitute an independent prognoPloS onee0315927https://www.ebi.ac.uk/biostudies/studies/S-EPMC11801720biostudies-literatureCuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment.PMC11801720Zhang JChen YZheng WXu HfalseCuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment.Despite the availability of various treatment options, glioblastoma (GBM) remains an extremely aggressive form of glioma with a poor prognosis. In recent studies, regulatory cell death (RCD) has been identified as an effective mechanism to suppress glioma. Cuproptosis, caused by intracellular copper, is a novel RCD process that affects chemotherapy efficacy and glioma progression; however, the precise function of cuproptosis-related lncRNAs (CRLs) and cuproptosis-related genes (CRGs) in GBM remains uncertain. To determine whether CRLs and CRGs have prognostic significance, a GBM cohort in TCGA to build a novel cuproptosis-related risk model. Two high-risk CRLs (AC091182.2, AC005229.4) and their co-expression CRGs (LIPT2, GLS) were identified and verified to constitute an independent progno2025-01-01T00:00:00Z20252025-04-04T01:37:09.682Z2025-04-04T01:37:09.682ZS-EPMC118017203991360710.1371/journal.pone.0315927