{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["147(1)"],"submitter":["Nientiedt M"],"pubmed_abstract":["<h4>Purpose</h4>To investigate the mRNA expression of B-MYB and MDM2 together with their p53 relatedness in clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>Genes were screened for their mRNA expression from 529 patients in a publicly available ccRCC cohort (TCGA). A cohort of 101 patients with ccRCC served as validation by qRT-PCR mRNA tissue expression analysis.<h4>Results</h4>Expression: B-MYB expression was significantly higher in high-grade tumours (p < 0.0001 and p = 0.048) and in advanced stages (p = 0.005 and p = 0.037) in both cohorts. Correlation: p53-B-MYB as well as MDM2-B-MYB showed significant correlations in local and low-grade ccRCCs, but not in high grade tumours or advanced stages (r < 0.3 and/or p > 0.05). Survival: Multivariable Cox regression of the TCGA cohort "],"journal":["Journal of cancer research and clinical oncology"],"pagination":["129-138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11802152"],"repository":["biostudies-literature"],"pubmed_title":["B-MYB-p53-related relevant regulator for the progression of clear cell renal cell carcinoma."],"pmcid":["PMC11802152"],"pubmed_authors":["Muller K","Kriegmair MC","Waldbillig F","Nientiedt M","Erben P","Porubsky S","Nitschke K","Steidler A","Popovic ZV","Muhlbauer J"],"additional_accession":[]},"is_claimable":false,"name":"B-MYB-p53-related relevant regulator for the progression of clear cell renal cell carcinoma.","description":"<h4>Purpose</h4>To investigate the mRNA expression of B-MYB and MDM2 together with their p53 relatedness in clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>Genes were screened for their mRNA expression from 529 patients in a publicly available ccRCC cohort (TCGA). A cohort of 101 patients with ccRCC served as validation by qRT-PCR mRNA tissue expression analysis.<h4>Results</h4>Expression: B-MYB expression was significantly higher in high-grade tumours (p < 0.0001 and p = 0.048) and in advanced stages (p = 0.005 and p = 0.037) in both cohorts. Correlation: p53-B-MYB as well as MDM2-B-MYB showed significant correlations in local and low-grade ccRCCs, but not in high grade tumours or advanced stages (r < 0.3 and/or p > 0.05). Survival: Multivariable Cox regression of the TCGA cohort ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-03-27T16:59:08.192Z","creation":"2025-08-28T03:09:03.579Z"},"accession":"S-EPMC11802152","cross_references":{"pubmed":["32951068"],"doi":["10.1007/s00432-020-03392-7"]}}