biostudies-literatureUnknown147(1)Nientiedt M<h4>Purpose</h4>To investigate the mRNA expression of B-MYB and MDM2 together with their p53 relatedness in clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>Genes were screened for their mRNA expression from 529 patients in a publicly available ccRCC cohort (TCGA). A cohort of 101 patients with ccRCC served as validation by qRT-PCR mRNA tissue expression analysis.<h4>Results</h4>Expression: B-MYB expression was significantly higher in high-grade tumours (p < 0.0001 and p = 0.048) and in advanced stages (p = 0.005 and p = 0.037) in both cohorts. Correlation: p53-B-MYB as well as MDM2-B-MYB showed significant correlations in local and low-grade ccRCCs, but not in high grade tumours or advanced stages (r < 0.3 and/or p > 0.05). Survival: Multivariable Cox regression of the TCGA cohort Journal of cancer research and clinical oncology129-138https://www.ebi.ac.uk/biostudies/studies/S-EPMC11802152biostudies-literatureB-MYB-p53-related relevant regulator for the progression of clear cell renal cell carcinoma.PMC11802152Muller KKriegmair MCWaldbillig FNientiedt MErben PPorubsky SNitschke KSteidler APopovic ZVMuhlbauer JfalseB-MYB-p53-related relevant regulator for the progression of clear cell renal cell carcinoma.<h4>Purpose</h4>To investigate the mRNA expression of B-MYB and MDM2 together with their p53 relatedness in clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>Genes were screened for their mRNA expression from 529 patients in a publicly available ccRCC cohort (TCGA). A cohort of 101 patients with ccRCC served as validation by qRT-PCR mRNA tissue expression analysis.<h4>Results</h4>Expression: B-MYB expression was significantly higher in high-grade tumours (p < 0.0001 and p = 0.048) and in advanced stages (p = 0.005 and p = 0.037) in both cohorts. Correlation: p53-B-MYB as well as MDM2-B-MYB showed significant correlations in local and low-grade ccRCCs, but not in high grade tumours or advanced stages (r < 0.3 and/or p > 0.05). Survival: Multivariable Cox regression of the TCGA cohort 2021-01-01T00:00:00Z2021 Jan2026-03-27T16:59:08.192Z2025-08-28T03:09:03.579ZS-EPMC118021523295106810.1007/s00432-020-03392-7