{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elston TW"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD)"],"pagination":["374-382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11802454"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(2)"],"pubmed_abstract":["What is good in one scenario may be bad in another. Despite the ubiquity of such contextual reasoning in everyday choice, how the brain flexibly uses different valuation schemes across contexts remains unknown. We addressed this question by monitoring neural activity from the hippocampus (HPC) and orbitofrontal cortex (OFC) of two monkeys performing a state-dependent choice task. We found that HPC neurons encoded state information as it became available and then, at the time of choice, relayed this information to the OFC via theta synchronization. During choice, the OFC represented value in a state-dependent manner; many OFC neurons uniquely coded for value in only one state but not the other. This suggests a functional dissociation whereby the HPC encodes contextual information that is broadcast to the OFC via theta synchronization to select a state-appropriate value subcircuit, thereby allowing for contextual reasoning in value-based choice."],"journal":["Nature neuroscience"],"pubmed_title":["Context-dependent decision-making in the primate hippocampal-prefrontal circuit."],"pmcid":["PMC11802454"],"funding_grant_id":["R01-MH117763","R01-MH121448","R01 MH121448","R01 MH117763"],"pubmed_authors":["Elston TW","Wallis JD"],"additional_accession":[]},"is_claimable":false,"name":"Context-dependent decision-making in the primate hippocampal-prefrontal circuit.","description":"What is good in one scenario may be bad in another. Despite the ubiquity of such contextual reasoning in everyday choice, how the brain flexibly uses different valuation schemes across contexts remains unknown. We addressed this question by monitoring neural activity from the hippocampus (HPC) and orbitofrontal cortex (OFC) of two monkeys performing a state-dependent choice task. We found that HPC neurons encoded state information as it became available and then, at the time of choice, relayed this information to the OFC via theta synchronization. During choice, the OFC represented value in a state-dependent manner; many OFC neurons uniquely coded for value in only one state but not the other. This suggests a functional dissociation whereby the HPC encodes contextual information that is broadcast to the OFC via theta synchronization to select a state-appropriate value subcircuit, thereby allowing for contextual reasoning in value-based choice.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T23:59:28.725Z","creation":"2025-04-04T23:59:28.725Z"},"accession":"S-EPMC11802454","cross_references":{"pubmed":["39762657"],"doi":["10.1038/s41593-024-01839-5"]}}