biostudies-literatureSalmanton-Garcia JEuropean Hematology Association358-374https://www.ebi.ac.uk/biostudies/studies/S-EPMC11803548biostudies-literatureUnknown100(3)Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), orAmerican journal of hematologyRespiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.PMC11803548CRTH74Martin-Perez SPapa MVMarchesi FEspigado IStojanoski ZDelia MZak PMagyari FSgherza NLimongelli AFianchi LGrafe SKWeinbergerova BWojtyniak EBatinic JStoma IAujayeb APagano LFalces-Romero IFarina FMitrovic MPantic NLeotta DVisek BLahmer TColovic NDrozd-Sokolowska JNappi DLopez-Garcia ACriscuolo MCornely OAVarricchio GSchonlein MDrgona LBuquicchio CMiranda-Castillo CLabrador JErben NMusto PNavratil MBavastro MHeras-Fernando IBrunetti SCVinh DCPetzer VCerchione CDel Principe MIFracchiolla NSAnastasopoulou ANvan den Ven LEisa NGlenthoj APiukovics KTlusty JGavriilaki ESalmanton-Garcia JDavila-Valls JCuccaro ACallejas-Charavia MAiello TFPlantefeve GCordoba RDabrowska-Iwanicka ARomano AAlmasari AMackenzie ESamarkos MAntic DSciume MMerelli MIdrizovic LCattaneo CGarcia-Vidal CPrezioso LArellano EPinczes LIPrin RMayer JCvetanoski MBiernat MMOtasevic VCernan MMarchetti MWolf DBilgin YMErdem Svan Praet JGora JBusca AGarcia-Ramirez PAdzic-Vukicevic TVena ABakker MHersby DSKhostelidi SMagliano GCoppola NKhedr RAMagdziak ADargenio MfalseRespiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or2025-01-01T00:00:00Z2025 Mar2026-06-03T02:48:12.666Z2025-04-03T23:57:35.909ZS-EPMC118035483971506910.1002/ajh.27565