{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["80(2)"],"submitter":["Mastalerz L"],"funding":["Narodowe Centrum Nauki"],"pubmed_abstract":["<h4>Background</h4>15-oxo-eicosatetraenoic acid (15-oxo-ETE), is a product of arachidonic acid (AA) metabolism in the 15-lipoxygenase-1 (15-LOX-1) pathway. 15-oxo-ETE was overproduced in the nasal polyps of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). In this study we investigated the systemic biosynthesis of 15-oxo-ETE and leukotriene E<sub>4</sub> (LTE<sub>4</sub>) and assessed their diagnostic value to identify patients with N-ERD.<h4>Methods</h4>The study included 64 patients with N-ERD, 59 asthmatics who tolerated aspirin well (ATA), and 51 healthy controls. A thorough clinical characteristics of asthmatics included computed tomography of paranasal sinuses. Plasma and urinary 15-oxo-ETE levels, and urinary LTE<sub>4</sub> excretion were me"],"journal":["Allergy"],"pagination":["534-544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11804310"],"repository":["biostudies-literature"],"pubmed_title":["Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE&lt;sub&gt;4&lt;/sub&gt; excretion."],"pmcid":["PMC11804310"],"pubmed_authors":["Sanak M","Szaleniec J","Trad G","Jakiela B","Gielicz A","Mastalerz L","Plutecka H","Gawlewicz-Mroczka A","Szatkowski P","Kacorzyk R","Cmiel A"],"additional_accession":[]},"is_claimable":false,"name":"Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE&lt;sub&gt;4&lt;/sub&gt; excretion.","description":"<h4>Background</h4>15-oxo-eicosatetraenoic acid (15-oxo-ETE), is a product of arachidonic acid (AA) metabolism in the 15-lipoxygenase-1 (15-LOX-1) pathway. 15-oxo-ETE was overproduced in the nasal polyps of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). In this study we investigated the systemic biosynthesis of 15-oxo-ETE and leukotriene E<sub>4</sub> (LTE<sub>4</sub>) and assessed their diagnostic value to identify patients with N-ERD.<h4>Methods</h4>The study included 64 patients with N-ERD, 59 asthmatics who tolerated aspirin well (ATA), and 51 healthy controls. A thorough clinical characteristics of asthmatics included computed tomography of paranasal sinuses. Plasma and urinary 15-oxo-ETE levels, and urinary LTE<sub>4</sub> excretion were me","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T01:32:42.546Z","creation":"2025-04-04T01:32:42.546Z"},"accession":"S-EPMC11804310","cross_references":{"pubmed":["39180224"],"doi":["10.1111/all.16281"]}}