biostudies-literatureUnknown80(2)Mastalerz LNarodowe Centrum Nauki<h4>Background</h4>15-oxo-eicosatetraenoic acid (15-oxo-ETE), is a product of arachidonic acid (AA) metabolism in the 15-lipoxygenase-1 (15-LOX-1) pathway. 15-oxo-ETE was overproduced in the nasal polyps of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). In this study we investigated the systemic biosynthesis of 15-oxo-ETE and leukotriene E₄ (LTE₄) and assessed their diagnostic value to identify patients with N-ERD.<h4>Methods</h4>The study included 64 patients with N-ERD, 59 asthmatics who tolerated aspirin well (ATA), and 51 healthy controls. A thorough clinical characteristics of asthmatics included computed tomography of paranasal sinuses. Plasma and urinary 15-oxo-ETE levels, and urinary LTE₄ excretion were meAllergy534-544https://www.ebi.ac.uk/biostudies/studies/S-EPMC11804310biostudies-literatureAspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE&lt;sub&gt;4&lt;/sub&gt; excretion.PMC11804310Sanak MSzaleniec JTrad GJakiela BGielicz AMastalerz LPlutecka HGawlewicz-Mroczka ASzatkowski PKacorzyk RCmiel AfalseAspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE&lt;sub&gt;4&lt;/sub&gt; excretion.<h4>Background</h4>15-oxo-eicosatetraenoic acid (15-oxo-ETE), is a product of arachidonic acid (AA) metabolism in the 15-lipoxygenase-1 (15-LOX-1) pathway. 15-oxo-ETE was overproduced in the nasal polyps of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). In this study we investigated the systemic biosynthesis of 15-oxo-ETE and leukotriene E₄ (LTE₄) and assessed their diagnostic value to identify patients with N-ERD.<h4>Methods</h4>The study included 64 patients with N-ERD, 59 asthmatics who tolerated aspirin well (ATA), and 51 healthy controls. A thorough clinical characteristics of asthmatics included computed tomography of paranasal sinuses. Plasma and urinary 15-oxo-ETE levels, and urinary LTE₄ excretion were me2025-01-01T00:00:00Z2025 Feb2025-04-04T01:32:42.546Z2025-04-04T01:32:42.546ZS-EPMC118043103918022410.1111/all.16281