biostudies-literatureUnknown15(1)Ishizuya YWe have reported that the FAN score, which consists of the fibrosis-4 (Fib-4) index, albumin-bilirubin (ALBI) score, and neutrophil-lymphocyte ratio (NLR), is a prognostic marker for patients receiving pembrolizumab for mUC. However, it remains unclear whether the FAN score is a prognostic factor for platinum-based first-line chemotherapy. We included 126 patients with mUC who received platinum-based first-line chemotherapy. The median PFS and overall survival (OS) were 6.3 months (95% confidence interval [CI] 4.5-8.0) and 14.0 months (95% CI 11.1-16.9), respectively. Multivariable analysis showed that Fib-4 index (HR 3.85, 95% CI 1.09-13.58, p = 0.036), ALBI score (HR 1.53, 95% CI 1.01-2.31, p = 0.045), and NLR (HR 1.76, 95% CI 1.14-2.71, p = 0.010) were independently associated with PFS.Scientific reports4640https://www.ebi.ac.uk/biostudies/studies/S-EPMC11806037biostudies-literatureFAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma.PMC11806037Nonomura NUemura THayashi TOkuda YKato TYoshimura AYamamichi GOka TTani MIshizuya YYamamoto YKawashima AHoribe YNesrine SYamamoto AYutong LHatano KfalseFAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma.We have reported that the FAN score, which consists of the fibrosis-4 (Fib-4) index, albumin-bilirubin (ALBI) score, and neutrophil-lymphocyte ratio (NLR), is a prognostic marker for patients receiving pembrolizumab for mUC. However, it remains unclear whether the FAN score is a prognostic factor for platinum-based first-line chemotherapy. We included 126 patients with mUC who received platinum-based first-line chemotherapy. The median PFS and overall survival (OS) were 6.3 months (95% confidence interval [CI] 4.5-8.0) and 14.0 months (95% CI 11.1-16.9), respectively. Multivariable analysis showed that Fib-4 index (HR 3.85, 95% CI 1.09-13.58, p = 0.036), ALBI score (HR 1.53, 95% CI 1.01-2.31, p = 0.045), and NLR (HR 1.76, 95% CI 1.14-2.71, p = 0.010) were independently associated with PFS.2025-01-01T00:00:00Z2025 Feb2025-04-04T02:43:16.011Z2025-04-04T02:43:16.011ZS-EPMC118060373992010310.1038/s41598-025-86212-7