{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie F"],"funding":["Research Project of Jiangsu Commission of Health","National Natural Science Foundation of China","Social Development Foundation of Zhenjiang","Natural Science Foundation of Jiangsu Province"],"pagination":["215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11806540"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>The homeobox (HOX) genes especially for HOXA cluster play crucial roles in leukemogenesis. HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. However, very few studies determined the DNA methylation-mediated epigenetic regulation of the HOXA cluster genes in AML.<h4>Methods</h4>We systematically first screened the prognostic value of HOXA cluster genes methylation in AML from The Cancer Genome Atlas (TCGA) datasets. Afterwards, the candidate prognosis-related gene HOXA9 were selected for clinical relevance analysis and were further validated in another independent cohort from our research center.<h4>Results</h4>The methylation of HOXA9, among HOXA cluster genes, negative"],"journal":["BMC cancer"],"pubmed_title":["Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia."],"pmcid":["PMC11806540"],"funding_grant_id":["82100183","M2022123","SH2023009","82270179","BK20221287","82300164","BK20230296","SH2022027"],"pubmed_authors":["Qian J","Xie F","Zhao YJ","Wang Y","Zhou JD","Zhang XL","Xu ZJ","Zhang TJ","Qiao L"],"additional_accession":[]},"is_claimable":false,"name":"Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia.","description":"<h4>Background</h4>The homeobox (HOX) genes especially for HOXA cluster play crucial roles in leukemogenesis. HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. However, very few studies determined the DNA methylation-mediated epigenetic regulation of the HOXA cluster genes in AML.<h4>Methods</h4>We systematically first screened the prognostic value of HOXA cluster genes methylation in AML from The Cancer Genome Atlas (TCGA) datasets. Afterwards, the candidate prognosis-related gene HOXA9 were selected for clinical relevance analysis and were further validated in another independent cohort from our research center.<h4>Results</h4>The methylation of HOXA9, among HOXA cluster genes, negative","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T01:34:01.225Z","creation":"2025-04-04T01:34:01.225Z"},"accession":"S-EPMC11806540","cross_references":{"pubmed":["39920624"],"doi":["10.1186/s12885-025-13633-y"]}}