biostudies-literatureYan XCapital's Funds for Health Improvement and Research62https://www.ebi.ac.uk/biostudies/studies/S-EPMC11806895biostudies-literatureUnknown25(1)<h4>Objectives</h4>Postoperative nausea and vomiting (PONV) is common after video-assisted thoracic surgery, which may be associated with the use of intraoperative opioids. We tested the hypothesis that balanced opioid-free anesthesia (OFA) might reduce the incidence of PONV after video-assisted thoracic surgery.<h4>Methods</h4>One hundred and sixty-eight adults undergoing video-assisted thoracic assisted surgery were randomly assigned to receive balanced opioid-free anesthesia or balanced opioid-based anesthesia (OBA). The primary outcome was the incidence of PONV, which was assessed with the Myles's simplified PONV impact scale during the initial 24 h after surgery.<h4>Results</h4>Compared with OBA group, the overall incidence of PONV in OFA group was significant reduced (14.6% vs. 30.1%BMC anesthesiologyEffects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial.PMC118068952022-2Z-2039Liang CJiang JJi YWu ASWei CWYan XfalseEffects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial.<h4>Objectives</h4>Postoperative nausea and vomiting (PONV) is common after video-assisted thoracic surgery, which may be associated with the use of intraoperative opioids. We tested the hypothesis that balanced opioid-free anesthesia (OFA) might reduce the incidence of PONV after video-assisted thoracic surgery.<h4>Methods</h4>One hundred and sixty-eight adults undergoing video-assisted thoracic assisted surgery were randomly assigned to receive balanced opioid-free anesthesia or balanced opioid-based anesthesia (OBA). The primary outcome was the incidence of PONV, which was assessed with the Myles's simplified PONV impact scale during the initial 24 h after surgery.<h4>Results</h4>Compared with OBA group, the overall incidence of PONV in OFA group was significant reduced (14.6% vs. 30.1%2025-01-01T00:00:00Z2025 Feb2026-06-02T07:13:13.861Z2025-04-06T07:42:01.571ZS-EPMC118068953992301610.1186/s12871-025-02938-x