biostudies-literatureUnknown15(6)Manoj Kumar SA new phenanthridine appended quinoline-based chemoreceptor 5-(5-(quinolin-8-yl)thiophen-2-yl)-tetrahydrodibenzo[a,i]phenanthridine (PHQBA) was successfully synthesized and characterized by ¹H, ¹³C, and HRMS spectral analyses. The promising chelation-induced process in PHQBA was accelerated by Th⁴⁺ ions, which impart robust ratiometric green fluorescence at 515 nm. The host-guest complex formed in a 1 : 1 binding stoichiometry between Th⁴⁺ ions and PHQBA was demonstrated by Jobs plot experiments. The Benesi-Hildebrand (BH) plot was employed to compute the binding constant for the complexation of PHQBA + Th⁴⁺, which was determined to be 3.77 × 10⁵ M^-1. To comprehend the detection mechanism of PHQBA, DFT, and TDDFT,RSC advances4546-4552https://www.ebi.ac.uk/biostudies/studies/S-EPMC11808482biostudies-literatureRatiometric discrimination of Th<sup>4+</sup> ions by a fluorogenic quinoline appended phenanthridine sensor and its applications.PMC11808482Munusamy SManoj Kumar SEnbanathan SKulathu Iyer SRanganadin SfalseRatiometric discrimination of Th<sup>4+</sup> ions by a fluorogenic quinoline appended phenanthridine sensor and its applications.A new phenanthridine appended quinoline-based chemoreceptor 5-(5-(quinolin-8-yl)thiophen-2-yl)-tetrahydrodibenzo[a,i]phenanthridine (PHQBA) was successfully synthesized and characterized by ¹H, ¹³C, and HRMS spectral analyses. The promising chelation-induced process in PHQBA was accelerated by Th⁴⁺ ions, which impart robust ratiometric green fluorescence at 515 nm. The host-guest complex formed in a 1 : 1 binding stoichiometry between Th⁴⁺ ions and PHQBA was demonstrated by Jobs plot experiments. The Benesi-Hildebrand (BH) plot was employed to compute the binding constant for the complexation of PHQBA + Th⁴⁺, which was determined to be 3.77 × 10⁵ M^-1. To comprehend the detection mechanism of PHQBA, DFT, and TDDFT,2025-01-01T00:00:00Z2025 Feb2025-04-26T16:28:41.649Z2025-04-06T15:14:46.948ZS-EPMC118084823993141910.1039/d4ra08840a